Department of Orthopedics, 960th Hospital of PLA, Jinan, China.
Front Cell Infect Microbiol. 2023 Aug 4;13:1228376. doi: 10.3389/fcimb.2023.1228376. eCollection 2023.
Treatment of spinal brucellosis with bilateral psoas abscess is a challenging clinical endeavor. We retrospectively evaluated a case of lumbar infection and bilateral psoas abscess, and was effectively managed through a unilateral extreme lateral approach with the aid of NPWT for bilateral drainage. We hypothesize that NPWT can influence the Piezo1 receptor of neutrophils and further influence the interaction between neutrophils and endothelial cells to promote the clearance of infected lesions, and this phenomenon is also observed in pathological slides. This proves that NPWT can rapidly enhance the recruitment of neutrophils in the infected area and improve the local immune response, and after a year of reassessment and tracking, Bilateral drainage using NPWT via a unilateral Extreme Lateral Approach could acquire satisfactory surgical outcomes, can be used as a treatment modality for lumbar infection with bilateral psoas abscesses.
双侧腰大肌脓肿的脊柱布鲁氏菌病的治疗是一项具有挑战性的临床工作。我们回顾性评估了一例腰椎感染和双侧腰大肌脓肿病例，并通过单侧极外侧入路联合 NPWT 双侧引流有效地进行了治疗。我们假设 NPWT 可以影响中性粒细胞的 Piezo1 受体，并进一步影响中性粒细胞和内皮细胞之间的相互作用，以促进感染病灶的清除，这一现象在病理切片中也观察到。这证明 NPWT 可以迅速增强感染区域中性粒细胞的募集，并改善局部免疫反应，经过一年的重新评估和跟踪，单侧极外侧入路联合 NPWT 的双侧引流可以获得满意的手术效果，可作为治疗双侧腰大肌脓肿腰椎感染的一种方法。
