Zhu Lin, Wang Yixuan, Pan Calvin Q, Xing Huichun
Center of Liver Diseases Division 3, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Division of Gastroenterology and Hepatology, BaoJi Central Hospital, Shaanxi, China.
Front Pharmacol. 2023 Aug 4;14:1258062. doi: 10.3389/fphar.2023.1258062. eCollection 2023.
Alcohol-related liver disease (ALD) from excessive alcohol intake has a unique gut microbiota profile. The disease progression-free survival in ALD patients has been associated with the degree of gut dysbiosis. The vicious cycles between gut dysbiosis and the disease progression in ALD including: an increase of acetaldehyde production and bile acid secretion, impaired gut barrier, enrichment of circulating microbiota, toxicities of microbiota metabolites, a cascade of pro-inflammatory chemokines or cytokines, and augmentation in the generation of reactive oxygen species. The aforementioned pathophysiology process plays an important role in different disease stages with a spectrum of alcohol hepatitis, ALD cirrhosis, neurological dysfunction, and hepatocellular carcinoma. This review aims to illustrate the pathophysiology of gut microbiota and clarify the gut-brain crosstalk in ALD, which may provide the opportunity of identifying target points for future therapeutic intervention in ALD.
过量饮酒导致的酒精性肝病（ALD）具有独特的肠道微生物群特征。ALD患者的无疾病进展生存期与肠道生态失调程度有关。ALD中肠道生态失调与疾病进展之间的恶性循环包括：乙醛生成和胆汁酸分泌增加、肠道屏障受损、循环微生物群富集、微生物群代谢产物的毒性、一系列促炎趋化因子或细胞因子以及活性氧生成增加。上述病理生理过程在酒精性肝炎、ALD肝硬化、神经功能障碍和肝细胞癌等不同疾病阶段发挥着重要作用。本综述旨在阐述肠道微生物群的病理生理学，并阐明ALD中的肠-脑相互作用，这可能为确定ALD未来治疗干预的靶点提供机会。
