Provenza J M, Klotz S A, Penn R L
J Clin Microbiol. 1986 Sep;24(3):453-5. doi: 10.1128/jcm.24.3.453-455.1986.
The isolation of Francisella tularensis from blood culture is extremely rare; a review of the literature produced only five documented cases. However, over a recent 17-month period we saw four cases of tularemia in which the organism was isolated in blood culture. The clinical presentations of our patients and those reported previously were very similar. Most of the patients had a significant underlying disease and presented with the typhoidal form of tularemia. Furthermore, all our patients had sepsis, pleuropulmonary disease, and rhabdomyolysis. Tularemia agglutinins were not performed on admission serum specimens or were nondiagnostic. All the F. tularensis isolates from blood culture in our series and most of the recent documented cases were obtained in radiometric blood culture systems, which may be more sensitive than conventional systems for detecting this fastidious microorganism.
从血培养中分离出土拉弗朗西斯菌极为罕见；文献回顾仅发现5例有记录的病例。然而，在最近17个月的时间里，我们遇到了4例兔热病病例，其中该病原体是从血培养中分离出来的。我们的患者与之前报道的患者临床表现非常相似。大多数患者有严重的基础疾病，并表现为伤寒型兔热病。此外，我们所有的患者都有败血症、胸膜肺部疾病和横纹肌溶解。入院时血清标本未检测土拉菌凝集素或检测结果无诊断意义。我们系列中所有从血培养分离出的土拉弗朗西斯菌以及最近大多数有记录的病例都是在放射性血培养系统中获得的，该系统对于检测这种苛求的微生物可能比传统系统更敏感。
