重组干扰素-α 2对皮质醇的刺激作用。

Cortisol stimulation by recombinant interferon-alpha 2.

作者信息

Roosth J, Pollard R B, Brown S L, Meyer W J

出版信息

J Neuroimmunol. 1986 Oct;12(4):311-6. doi: 10.1016/0165-5728(86)90037-8.

Abstract

Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-alpha 2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-alpha 2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 X 10(6) units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

摘要

采用放射免疫分析法测定了接受重组干扰素α-2实验性治疗的癌症患者的血清皮质醇浓度。注射干扰素后，皮质醇浓度稳步上升，在肌肉注射干扰素α-2后8小时，其浓度与对照日有显著差异。随着干扰素每周剂量的增加（0 - 120×10⁶单位），皮质醇升高也增加。近期关于干扰素治疗神经疾病和恶性疾病的临床试验迫切需要了解外源性给予干扰素的作用和副作用。