Hasbani G El, Megahed A, Cassetta M
"St Vincent's" Medical Center.
Bridgeport Hospital, Bridgeport, United States.
Acta Endocrinol (Buchar). 2023 Jan-Mar;19(1):131-132. doi: 10.4183/aeb.2023.131. Epub 2023 Aug 14.
Uncontrolled chronic gout can lead to deposition of monosodium urate crystals, better known as tophi. Such depositions can involve several organ systems, including unusual locations such as the vertebrae. Nevertheless, certain complications, such as hypercalcemia, can arise because of tophi. Despite an aggressive intervention, hypercalcemia might not resolve spontaneously, as long as an ongoing inflammatory process secondary to gouty tophi is taking place. Herein, we present the case of a 62-year-old man with a long history of gouty tophi who presented for back pain and was found to have spinal cord involvement with PTH-independent hypercalcemia which only resolved with pegloticase therapy.
未得到控制的慢性痛风可导致尿酸单钠晶体沉积，即众所周知的痛风石。这种沉积可累及多个器官系统，包括一些不常见的部位，如脊椎。然而，痛风石可引发某些并发症，如高钙血症。尽管采取了积极的干预措施，但只要痛风石继发的炎症过程持续存在，高钙血症可能不会自行缓解。在此，我们报告一例62岁男性患者，该患者有痛风石病史，因背痛就诊，发现脊髓受累并伴有非甲状旁腺激素依赖性高钙血症，仅通过聚乙二醇化尿酸酶治疗后才得以缓解。
