Sun Jiao, Wang Jialin, You Ran, Wang Yanling
Department of Ophthalmology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
J Ophthalmol. 2018 Sep 30;2018:7895238. doi: 10.1155/2018/7895238. eCollection 2018.
The association between -peripapillary atrophy and the retinal vasculature in nonpathological high myopia is unclear. The aim of this study is to investigate whether -peripapillary atrophy contribute to the changes of the retinal vasculature using optical coherence tomography angiography.
In a cross-sectional study, one hundred and thirty eyes with nonpathological high myopia were included. -peripapillary atrophy was analysed using Image J software based on fundus photographs. A 3.0 × 3.0 mm grid and a 4.5 × 4.5 mm grid were used to scan parafoveal and peripapillary regions using optical coherence tomography angiography, respectively. Vessel density and fractal dimensions of the retina and foveal avascular zone were analysed and quantified using en face projection images. Correlations between the vascular density, foveal avascular zone, and -peripapillary atrophy were determined.
Using multivariate analysis, -peripapillary atrophy was negatively correlated with the vessel density in radial peripapillary capillaries (=0.002) even after adjusting for other variables. This relationship was also confirmed in the macula (superficial retinal plexus: < 0.05; deep retinal plexus: < 0.05). The vessel densities in the nasal and inferior sectors were more strongly correlated with -peripapillary atrophy.
There was a negative correlation between -peripapillary atrophy and the retinal vasculature in highly myopic eyes, especially in radial peripapillary capillaries and deep retinal plexus. -peripapillary atrophy can be visualized and is a convenient structural feature that can benefit the early diagnosis and detection of chorioretinal atrophy in high myopia.
非病理性高度近视中视盘周围萎缩与视网膜血管系统之间的关联尚不清楚。本研究旨在使用光学相干断层扫描血管造影术研究视盘周围萎缩是否会导致视网膜血管系统的变化。
在一项横断面研究中，纳入了130只非病理性高度近视的眼睛。基于眼底照片，使用Image J软件对视盘周围萎缩进行分析。分别使用3.0×3.0mm网格和4.5×4.5mm网格，通过光学相干断层扫描血管造影术对视乳头旁和视盘周围区域进行扫描。使用表面投影图像分析并量化视网膜和黄斑无血管区的血管密度和分形维数。确定血管密度、黄斑无血管区和视盘周围萎缩之间的相关性。
使用多变量分析，即使在调整其他变量后，视盘周围萎缩与视盘周围放射状毛细血管的血管密度呈负相关（=0.002）。这种关系在黄斑区也得到了证实（视网膜浅丛：<0.05；视网膜深丛：<0.05）。鼻侧和下方扇形区域的血管密度与视盘周围萎缩的相关性更强。
高度近视眼的视盘周围萎缩与视网膜血管系统之间存在负相关关系，尤其是在视盘周围放射状毛细血管和视网膜深丛中。视盘周围萎缩可以可视化，是一种方便的结构特征，有助于高度近视脉络膜视网膜萎缩的早期诊断和检测。
