Wang Xiaolei, Kong Xiangmei, Jiang Chunhui, Li Mengwei, Yu Jian, Sun Xinghuai
Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, China Key Laboratory of Myopia, Ministry of Health (Fudan University), Shanghai, China Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), China.
BMJ Open. 2016 Mar 11;6(3):e010791. doi: 10.1136/bmjopen-2015-010791.
The aim of this study was to evaluate the peripapillary and parafoveal perfusion of young, healthy myopic subjects with spectral domain optical coherence tomography (OCT) angiography.
A prospective comparative study was conducted from December 2014 to January 2015.
Participants recruited from a population-based study performed by the Eye, Ear, Nose and Throat Hospital of Fudan University in Shanghai.
A total of 78 Chinese normal subjects (78 eyes) with different refraction were included. Myopia was divided into 4 groups on the basis of the refractive status: 20 eyes with emmetropia (mean spherical equivalent (MSE) 0.50D to -0.50D), 20 eyes with mild myopia (MSE -0.75D to -2.75D), 20 eyes with moderate myopia (MSE -3.00D to -5.75D), and 18 eyes with high myopia (MSE≤-6.00D).
Peripapillary and parafoveal retinal and choroidal perfusion parameters and their relationships with axial length (AL) and retinal nerve fibre layer (RNFL) thickness were analysed.
Significant differences were found for the retinal flow index and vessel density in the peripapillary area among the 4 groups, but not in the parafoveal area. The high myopia group had the lowest peripapillary retinal flow index and vessel density. In addition, there was a negative correlation (β=-0.002, p=0.047) between the AL and peripapillary retinal flow index and a positive correlation between RNFL thickness and the peripapillary retinal perfusion parameters (flow index: β=0.001, p=0.006; vessel density: β=0.350, p=0.002) even after adjustment for other variables.
Highly myopic eyes have a decreased peripapillary retinal perfusion compared with emmetropic eyes. Such vascular features might increase the susceptibility to vascular-related eye diseases.
本研究旨在利用频域光学相干断层扫描（OCT）血管造影术评估年轻健康近视受试者的视乳头周围和黄斑旁灌注情况。
2014年12月至2015年1月进行了一项前瞻性对照研究。
参与者来自复旦大学附属眼耳鼻喉科医院开展的一项基于人群的研究。
共纳入78名具有不同屈光状态的中国正常受试者（78只眼）。根据屈光状态将近视分为4组：20只正视眼（平均球镜当量（MSE）0.50D至 -0.50D），20只轻度近视眼（MSE -0.75D至 -2.75D），20只中度近视眼（MSE -3.00D至 -5.75D），以及18只高度近视眼（MSE≤-6.00D）。
分析视乳头周围和黄斑旁视网膜及脉络膜灌注参数及其与眼轴长度（AL）和视网膜神经纤维层（RNFL）厚度的关系。
4组之间视乳头周围区域的视网膜血流指数和血管密度存在显著差异，但黄斑旁区域无差异。高度近视组的视乳头周围视网膜血流指数和血管密度最低。此外，即使在对其他变量进行校正后，AL与视乳头周围视网膜血流指数之间仍存在负相关（β=-0.002，p=0.047），RNFL厚度与视乳头周围视网膜灌注参数之间存在正相关（血流指数：β=0.001，p=0.006；血管密度：β=0.350，p=0.002）。
与正视眼相比，高度近视眼的视乳头周围视网膜灌注减少。这种血管特征可能会增加患血管相关性眼病的易感性。
