在淀粉样蛋白呈阳性的遗忘型轻度认知障碍患者中，语义侵入错误与血浆Ptau-181相关。
Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive.
作者信息
Curiel Cid Rosie E, Ortega Alexandra, Crocco Elizabeth A, Hincapie Diana, McFarland Karen N, Duara Ranjan, Vaillancourt David, DeKosky Steven T, Smith Glenn, Sfakianaki Efrosyni, Rosselli Monica, Barker Warren W, Adjouadi Malek, Barreto Yarlenis, Feito Yuleidys, Loewenstein David A
机构信息
Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States.
Department of Neurology and the Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United States.
出版信息
Front Neurol. 2023 Aug 4;14:1179205. doi: 10.3389/fneur.2023.1179205. eCollection 2023.
INTRODUCTION
Semantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A-) on positron emission tomography (PET).
METHOD
This study examines the association between SI and plasma - based biomarkers. One hundred and twenty-eight participants received SiMoA derived measures of plasma pTau-181, ratio of two amyloid-β peptide fragments (Aβ42/Aβ40), Neurofilament Light protein (NfL), Glial Fibrillary Acidic Protein (GFAP), ApoE genotyping, and amyloid PET imaging.
RESULTS
The aMCI A+ ( = 42) group had a higher percentage of ApoE ɛ4 carriers, and greater levels of pTau-181 and SI, than Cognitively Unimpaired (CU) A- participants ( = 25). CU controls did not differ from aMCI A- ( = 61) on plasma biomarkers or ApoE genotype. Logistic regression indicated that ApoE ɛ4 positivity, pTau-181, and SI were independent differentiating predictors (Correct classification = 82.0%; Sensitivity = 71.4%; Specificity = 90.2%) in identifying A+ from A- aMCI cases.
DISCUSSION
A combination of plasma biomarkers, ApoE positivity and SI had high specificity in identifying A+ from A- aMCI cases.
引言
语义侵入错误（SI）已区分出在正电子发射断层扫描（PET）中淀粉样蛋白呈阳性（A+）与呈阴性（A-）的遗忘型轻度认知障碍（aMCI）患者。
方法
本研究考察了SI与基于血浆的生物标志物之间的关联。128名参与者接受了基于单分子阵列（SiMoA）的血浆pTau-181、两种淀粉样β肽片段的比率（Aβ42/Aβ40）、神经丝轻链蛋白（NfL）、胶质纤维酸性蛋白（GFAP）、载脂蛋白E基因分型以及淀粉样蛋白PET成像检测。
结果
与认知未受损（CU）的A-参与者（n = 25）相比，aMCI的A+组（n = 42）中载脂蛋白E ε4携带者的比例更高，pTau-181水平和SI更高。CU对照组在血浆生物标志物或载脂蛋白E基因型方面与aMCI的A-组（n = 61）没有差异。逻辑回归表明，在区分aMCI的A+和A-病例时，载脂蛋白E ε4阳性、pTau-181和SI是独立的鉴别预测因子（正确分类率 = 82.0%；灵敏度 = 71.4%；特异性 = 90.2%）。
讨论
血浆生物标志物、载脂蛋白E阳性和SI的组合在区分aMCI的A+和A-病例方面具有高特异性。
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