Nova Southeastern University, Davie, FL, USA.
Department of Psychiatry and Behavioral Sciences, Center for Cognitive Neuroscience and Aging, University of Miami Miller School of Medicine, Miami, FL, USA.
J Alzheimers Dis. 2020;73(2):785-790. doi: 10.3233/JAD-191022.
Semantic intrusion errors on memory tests may represent very early cognitive changes associated with elevated Alzheimer's disease pathology within the brain, including amyloid-β (Aβ). Subscales that measure proactive semantic interference (PSI) and intrusions related to PSI on the Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) have been associated with high levels of brain amyloid load, structural changes on brain MRI in Hispanic and non-Hispanic groups. It is presently unknown whether intrusion errors or other measures of the LASSI-L can differentiate between African-American (AA) older adults diagnosed with amnestic mild cognitive impairment (aMCI) or classified as cognitively normal (CN).
This study examined the extent to which a high percentage of semantic intrusion errors on LASSI-L subscales susceptible to PSI and other LASSI-L measures could differentiate between AA aMCI and CN groups.
Forty-eight AA older adults were recruited (27 CN and 21 aMCI) and received a through clinical and neuropsychological evaluation. The LASSI-L was administered independent of diagnostic classification.
With and without statistical adjustment for literacy, AA aMCI participants scored lower on all LASSI-L measures. ROC analyses revealed an area under the curve exceeding 90% and correctly classified 86% of AA aMCI with 82% specificity for AA CN participants.
Percentage of intrusion errors on the LASSI-L subscales susceptible to PSI differentiated AA aMCI from AA CN. This adds to emerging evidence indicating that the LASSI-L may be culturally appropriate and can differentiate between aMCI and CN in diverse ethnic/cultural groups.
记忆测试中的语义干扰错误可能代表与大脑中阿尔茨海默病病理学升高相关的非常早期的认知变化，包括淀粉样蛋白-β（Aβ）。衡量主动语义干扰（PSI）和与洛温斯坦·阿塞维多语义干扰和学习量表（LASSI-L）的 PSI 相关的侵入的子量表与大脑淀粉样蛋白负荷水平高、西班牙裔和非西班牙裔人群的大脑 MRI 结构变化相关。目前尚不清楚侵入错误或 LASSI-L 的其他测量指标是否可以区分被诊断为遗忘型轻度认知障碍（aMCI）的非裔美国人（AA）老年人或认知正常（CN）。
本研究考察了 LASSI-L 子量表上的高百分比语义侵入错误在多大程度上可以区分 AA aMCI 和 CN 组。
招募了 48 名 AA 老年人（27 名 CN 和 21 名 aMCI），并进行了全面的临床和神经心理学评估。LASSI-L 在不考虑诊断分类的情况下进行管理。
无论是否对识字进行统计调整，AA aMCI 参与者在所有 LASSI-L 测量上的得分都较低。ROC 分析显示曲线下面积超过 90%，正确分类了 86%的 AA aMCI，对 AA CN 参与者的特异性为 82%。
LASSI-L 子量表上的侵入错误百分比可区分 AA aMCI 和 AA CN。这增加了越来越多的证据表明，LASSI-L 可能具有文化适宜性，可以在不同的种族/文化群体中区分 aMCI 和 CN。
