Zheng D Diane, Cid Rosie E Curiel, Ortega Alexandra, Crocco Elizabeth A, Vaillancourt David, Armstrong Melissa J, Asken Breton, DeKosky Steven T, Adjouadi Malek, Smith Glenn, Duara Ranjan, Marsiske Michael, Rosselli Monica, W Barker Warren, Loewenstein David A
Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States.
Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States; 1Florida Alzheimer's Disease Research Center, Gainesville, FL 32610, United States.
Int Psychogeriatr. 2025 Mar;37(2):100005. doi: 10.1016/j.inpsyc.2024.100005. Epub 2024 Dec 4.
To evaluate the predictive utility of proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) deficits on the longitudinal everyday functional decline on the Clinical Dementia Rating Sum of Boxes (CDR-SOB) among older adults with amnestic mild cognitive impairment (aMCI).
Longitudinal prospective cohort study.
1Florida Alzheimer's Disease Research Center (1FLADRC).
97 older adults aged 54 to 98 years who were diagnosed with aMCI following a baseline evaluation. The average age was 71.9 years, 51 % male, average education 15.7 years, and 56 % Hispanic. The mean MMSE score was 28.0. Participants were followed annually for 3 to 4 visits with a mean follow-up time of 38.9 months (range 22.7 to 70.3 months).
CDR-SOB were obtained at each visit and the latent growth curve trajectory of CDR-SOB was estimated. The associations between PSI and frPSI and the growth curve trajectory of CDR-SOB were examined.
The growth curve model that best fits the CDR-SOB trajectory was a linear form and included the fixed and random effect of intercept and slope of time. After adjusting for age, sex, education, Hispanic background, Hopkins Verbal Learning Test (HVLT) immediate and delayed recall, and amyloid positivity, frPSI (β = -0.134, se=0.04, p < 0.01) remained statistically significant in predicting a steeper slope on the trajectory of decline in CDR-SOB.
frPSI at baseline predicted the rate of everyday functional decline over time among participants with aMCI regardless of amyloid status and demonstrated its utility of longitudinal prediction of change in CDR-SOB.
评估主动语义干扰（PSI）和无法从主动语义干扰中恢复（frPSI）缺陷对遗忘型轻度认知障碍（aMCI）老年人临床痴呆评定量表总和（CDR-SOB）纵向日常功能衰退的预测效用。
纵向前瞻性队列研究。
佛罗里达阿尔茨海默病研究中心（1FLADRC）。
97名年龄在54至98岁之间的老年人，他们在基线评估后被诊断为aMCI。平均年龄为71.9岁，51%为男性，平均受教育年限为15.7年，56%为西班牙裔。平均MMSE评分为28.0。参与者每年随访3至4次，平均随访时间为38.9个月（范围为22.7至70.3个月）。
每次随访时获取CDR-SOB，并估计CDR-SOB的潜在生长曲线轨迹。检查PSI和frPSI与CDR-SOB生长曲线轨迹之间的关联。
最适合CDR-SOB轨迹的生长曲线模型是线性形式，包括截距和时间斜率的固定效应和随机效应。在调整年龄、性别、教育程度、西班牙裔背景、霍普金斯言语学习测试（HVLT）即时和延迟回忆以及淀粉样蛋白阳性后，frPSI（β = -0.134，标准误 = 0.04，p < 0.01）在预测CDR-SOB下降轨迹上更陡的斜率方面仍具有统计学意义。
基线时的frPSI预测了aMCI参与者随时间的日常功能衰退率，无论淀粉样蛋白状态如何，并证明了其对CDR-SOB变化进行纵向预测的效用。
