Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Turkey.
Biomed Mater. 2023 Sep 1;18(5). doi: 10.1088/1748-605X/acf25c.
Diabetic wounds are one of the most challenging clinical conditions in diabetes, necessitating the development of new treatments to foster healing and prevent microbial contamination. In this study, polyvinyl alcohol was used as a matrix polymer, and amoxicillin (AMX) and salicylic acid (SA) were selected as bioactive compounds with antimicrobial (with AMX) and anti-inflammatory action (with SA) to obtain innovative drug-loaded electrospun nanofiber patches for the management of diabetic wounds. Scanning electron microscope images revealed the uniform and beadless structure of the nanofiber patches. Mechanical tests indicated that AMX minimally increased the tensile strength, while SA significantly reduced it. The patches demonstrated effective antibacterial activity against both gram-positive () and gram-negative () strains. The potential of these patches in the development of novel wound dressings is highlighted by the excellent biocompatibility with fibroblast cells maintained for up to 7 d.
糖尿病性创面是糖尿病最具挑战性的临床病症之一，需要开发新的治疗方法来促进愈合并防止微生物污染。在这项研究中，聚乙烯醇被用作基质聚合物，阿莫西林（AMX）和水杨酸（SA）被选择作为具有抗菌（AMX）和抗炎作用（SA）的生物活性化合物，以获得用于管理糖尿病性创面的创新载药电纺纳米纤维贴片。扫描电子显微镜图像显示出纳米纤维贴片的均匀和无珠状结构。力学测试表明，AMX 最小程度地增加了拉伸强度，而 SA 则显著降低了拉伸强度。这些贴片对革兰氏阳性（）和革兰氏阴性（）菌株均表现出有效的抗菌活性。这些贴片与成纤维细胞的良好生物相容性被强调，这些成纤维细胞可在长达 7 天的时间内维持。
