Wang Dongyu, Jin Jiale, Zhang Chengran, Ruan Chengxin, Qin Yifang, Li Dongdong, Guan Ming, Lei Pengfei
Department of Orthopedic Surgery, Xiangya Hospital Central South University, Changsha 410008, China.
Department of Orthopedic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou310058, China.
ACS Omega. 2024 Jan 16;9(4):4974-4985. doi: 10.1021/acsomega.3c08718. eCollection 2024 Jan 30.
Infectious wounds pose a significant challenge in the field of wound healing primarily due to persistent inflammation and the emergence of antibiotic-resistant bacteria. To combat these issues, the development of an effective wound dressing that can prevent infection and promote healing is of the utmost importance. Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment strategy for tackling antibiotic-resistant bacteria. A biodegradable photosensitizer called hematoporphyrin monomethyl ether (HMME) has shown potential in generating reactive oxygen species (ROS) upon laser activation to combat bacteria. However, the insolubility of HMME limits its antibacterial efficacy and its ability to facilitate skin healing. To overcome these limitations, we have synthesized a compound hydrogel by combining carbomer, HMME, and CuO nanoparticles. This compound hydrogel exhibits enhanced antimicrobial ability and excellent biocompatibility and promotes angiogenesis, which is crucial for the healing of skin defects. By integrating the benefits of HMME, CuO nanoparticles, and the gel-forming properties of carbomer, this compound hydrogel shows great potential as an effective wound dressing material. In summary, the compound hydrogel developed in this study offers a promising solution for infectious wounds by addressing the challenges of infection prevention and promoting skin healing. This innovative approach utilizing PDT and the unique properties of the compound hydrogel could significantly improve the outcomes of wound healing in clinical settings.
感染性伤口在伤口愈合领域构成了重大挑战，主要原因是持续的炎症以及抗生素耐药菌的出现。为应对这些问题，开发一种能够预防感染并促进愈合的有效伤口敷料至关重要。光动力疗法（PDT）已成为一种有前景的用于对付抗生素耐药菌的非侵入性治疗策略。一种名为单甲醚化血卟啉（HMME）的可生物降解光敏剂在激光激活后显示出产生活性氧（ROS）以对抗细菌的潜力。然而，HMME的不溶性限制了其抗菌功效及其促进皮肤愈合的能力。为克服这些限制，我们通过将卡波姆、HMME和氧化铜纳米颗粒结合合成了一种复合水凝胶。这种复合水凝胶具有增强的抗菌能力和出色的生物相容性，并能促进血管生成，这对皮肤缺损的愈合至关重要。通过整合HMME、氧化铜纳米颗粒的优点以及卡波姆的凝胶形成特性，这种复合水凝胶作为一种有效的伤口敷料材料显示出巨大潜力。总之，本研究开发的复合水凝胶通过应对预防感染和促进皮肤愈合的挑战，为感染性伤口提供了一种有前景的解决方案。这种利用PDT和复合水凝胶独特性质的创新方法可显著改善临床环境中伤口愈合的结果。
