齿果酸模根中的四个新的酚类成分

Four new phenolic constituents from the roots of Rumex dentatus L.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Science, Beijing 100049, PR China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.

出版信息

Fitoterapia. 2023 Oct;170:105657. doi: 10.1016/j.fitote.2023.105657. Epub 2023 Aug 20.

DOI:10.1016/j.fitote.2023.105657

PMID:37604244

Abstract

Four new phenolic compounds, including two naphthalenes, musizin-8-O-β-D-(6'-O-malonyl-3''-methoxy)glucopyranoside (1) and 2-acetyl-3-methyl-1,4-naphtho-quinone-8-O-β-D-glucopyranoside (2), one chromone, (2'R)-7-hydroxy-2-(2'-hydroxypropyl)-5-methyl acetate chromone (3), and one xanthone, 2,8-dimethyl-3,6-dihydroxyxanthone (4) were isolated from the roots of Rumex dentatus L. (Polygonaceae). In addition, five known including four naphthalenes (5-8) and one chromone (9) were also obtained. Their structures were determined by means of extensive spectroscopic analysis and acidic hydrolysis. Compound 1 showed moderate antifungal activity against Epidermophyton floccosum, with inhibitory rate of 39.539 ± 0.412% at a concentration of 100 μM.

摘要

从酸模（Polygonaceae）的根部分离得到四个新的酚类化合物，包括两个萘酚， musizin-8-O-β-D-(6'-O-丙二酰基-3''-甲氧基)吡喃葡萄糖苷（1）和 2-乙酰基-3-甲基-1,4-萘醌-8-O-β-D-吡喃葡萄糖苷（2），一个色酮，（2'R）-7-羟基-2-(2'-羟基丙基)-5-甲基乙酸酯色酮（3）和一个黄烷酮，2,8-二甲基-3,6-二羟基黄烷酮（4）。此外，还获得了五个已知化合物，包括四个萘酚（5-8）和一个色酮（9）。通过广泛的光谱分析和酸性水解确定了它们的结构。化合物 1 在 100μM 浓度下对絮状表皮癣菌（Epidermophyton floccosum）显示出中等的抗真菌活性，抑制率为 39.539±0.412%。