Bao Bingkun, Zeng Qingmei, Li Kai, Wen Jianfeng, Zhang Yiqing, Zheng Yongjun, Zhou Renjie, Shi Chutong, Chen Ting, Xiao Chaonan, Chen Baihang, Wang Tao, Yu Kang, Sun Yuan, Lin Qiuning, He Yong, Tu Shantung, Zhu Linyong
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, China.
Nat Mater. 2023 Oct;22(10):1253-1260. doi: 10.1038/s41563-023-01648-4. Epub 2023 Aug 21.
Hydrogel materials show promise for diverse applications, particular as biocompatible materials due to their high water content. Despite advances in hydrogel technology in recent years, their application is often severely limited by inadequate mechanical properties and time-consuming fabrication processes. Here we report a rapid hydrogel preparation strategy that achieves the simultaneous photo-crosslinking and establishment of biomimetic soft-hard material interface microstructures. These biomimetic interfacial-bonding nanocomposite hydrogels are prepared within seconds and feature clearly separated phases but have a strongly bonded interface. Due to effective interphase load transfer, biomimetic interfacial-bonding nanocomposite gels achieve an ultrahigh toughness (138 MJ m) and exceptional tensile strength (15.31 MPa) while maintaining a structural stability that rivals or surpasses that of commonly used elastomer (non-hydrated) materials. Biomimetic interfacial-bonding nanocomposite gels can be fabricated into arbitrarily complex structures via three-dimensional printing with micrometre-level precision. Overall, this work presents a generalizable preparation strategy for hydrogel materials and acrylic elastomers that will foster potential advances in soft materials.
水凝胶材料在多种应用中显示出前景，特别是作为生物相容性材料，因为它们具有高含水量。尽管近年来水凝胶技术取得了进展，但其应用常常受到机械性能不足和制造过程耗时的严重限制。在此，我们报告一种快速水凝胶制备策略，该策略实现了光交联和仿生软硬材料界面微结构的同时建立。这些仿生界面键合纳米复合水凝胶在几秒钟内制备而成，具有明显分离的相，但界面结合牢固。由于有效的相间载荷传递，仿生界面键合纳米复合凝胶在保持与常用弹性体（非水合）材料相当或超越其结构稳定性的同时，实现了超高韧性（138 MJ·m）和出色的拉伸强度（15.31 MPa）。仿生界面键合纳米复合凝胶可以通过具有微米级精度的三维打印制成任意复杂的结构。总体而言，这项工作为水凝胶材料和丙烯酸弹性体制备了一种可推广的策略，这将推动软材料领域的潜在进展。
