Qiu Jianyu, Kang Xitong, Liu Tao, Liu Jing, Liu Huansheng, Zhao Xiyang, Li Yong, Liu Qi, Nong Zhenzhen, Wang Qingwen, Liu Zhenzhen
Institute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Mater Today Bio. 2025 Jun 25;33:102017. doi: 10.1016/j.mtbio.2025.102017. eCollection 2025 Aug.
Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by one-step of directed freeze-casting technique via utilizing the FDA-approved poly (vinyl alcohol) (PVA) and carboxymethylcellulose nanofibril (CNF) as the network backbone without any chemical crosslinker. This fully physical crosslinked hydrogel exhibits remarkable mechanical performance because of the highly oriented microstructure and multiple hydrogen bonding, including the matching mechanical property with soft tissue, anti-tearing capability, the great 99 % retention of tensile stress and higher toughness after soaking at PBS for 7 days. And the extremely low swelling ratio of 5.9 % in PBS and combining the higher water-content is superior to other reported anti-swelling hydrogel. Importantly, besides as a robust physical barrier of this hydrogel patch, it also displays the excellent inflammatory regulation via capturing the positively charged proinflammatory cytokines because of the incorporation of the negatively charged CNF, synergistically promoting the remarkable anti-adhesion and tissue pro-healing efficiency. By integrating the anti-adhesion, tissue pro-healing, long-lasting anti-deformation in vivo and excellent bio-compatibility, this hydrogel provides a great candidate of anti-adhesion patch for tension-free repair operations.
临床中的无张力修复手术需要植入可植入网片来修复内部软组织缺损。然而，现有的临床补片无法同时实现抗粘连、抗变形和促进组织愈合。在此，通过一步定向冷冻铸造技术，利用美国食品药品监督管理局（FDA）批准的聚乙烯醇（PVA）和羧甲基纤维素纳米纤维（CNF）作为网络骨架，在无任何化学交联剂的情况下合成了一种高性能抗粘连水凝胶补片。这种完全物理交联的水凝胶由于具有高度取向的微观结构和多重氢键，表现出卓越的力学性能，包括与软组织匹配的力学性能、抗撕裂能力、在PBS中浸泡7天后拉伸应力保留率高达99%以及更高的韧性。并且其在PBS中的极低溶胀率为5.9%，结合较高的含水量，优于其他已报道的抗溶胀水凝胶。重要的是，除了作为这种水凝胶补片强大的物理屏障外，由于引入了带负电荷的CNF，它还通过捕获带正电荷的促炎细胞因子表现出优异的炎症调节作用，协同促进显著的抗粘连和组织愈合效率。通过整合抗粘连、促进组织愈合、体内持久抗变形以及优异的生物相容性，这种水凝胶为无张力修复手术提供了一种极佳的抗粘连补片候选材料。
