Marín-Martínez Florencio Manuel, Arense-Gonzalo Julian J, Artes Miriam Artes, Bobadilla Romero Emny Rochell, García Porcel Víctor Javier, Alcon Cerro Pablo, Suárez-Pineda Mabel Coromoto, Guzmán Martínez-Valls Pablo Luis, Mendiola Jaime
Urology Department, General Hospital Santa Lucía of Cartagena, Cartagena, Spain.
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine of the University of Murcia, Murcia, Spain.
Urologia. 2023 Nov;90(4):715-719. doi: 10.1177/03915603231192736. Epub 2023 Aug 22.
Evaluate the association between AGD and the risk of PCa.
Incident case-control study, conducted on 153 patients. All patients underwent prostate biopsy for abnormal digital rectal exam and/or prostate antigen elevation. Two variants of AGD [anus to scrotum base (AGDas) and anus to dorsal insertion of penis (AGDap) were measured. Student's t-test was used to analyze continuous variables and chi-square for discrete variables. Differences in AGD (raw and adjusted) measures between cases and controls were assessed using the ANCOVA test.
There is significant association between the diagnose of PCa and both AGD, patients diagnosed with PCa had both AGD measures shortened, in the crude and the full adjusted models.
This research suggests that the same gestational environmental exposures, could represent a weak androgen signaling and may also have an increased risk of prostate cancer.
评估肛门生殖距离（AGD）与前列腺癌（PCa）风险之间的关联。
对153例患者进行了病例对照研究。所有患者均因直肠指检异常和/或前列腺抗原升高接受了前列腺活检。测量了AGD的两种变体[从肛门到阴囊底部（AGDas）和从肛门到阴茎背侧插入点（AGDap）]。采用学生t检验分析连续变量，采用卡方检验分析离散变量。使用协方差分析（ANCOVA）检验评估病例组和对照组之间AGD（原始和调整后）测量值的差异。
在未调整和完全调整模型中，PCa诊断与两种AGD均存在显著关联，被诊断为PCa的患者两种AGD测量值均缩短。
本研究表明，相同的孕期环境暴露可能代表雄激素信号较弱，也可能增加患前列腺癌的风险。
