Maldonado-Cárceles Ana B, Sánchez-Rodríguez Carlos, Vera-Porras Eva M, Árense-Gonzalo Julián J, Oñate-Celdrán Julián, Samper-Mateo Paula, García-Escudero Damián, Torres-Roca Marcos, Martínez-Díaz Francisco, Mendiola Jaime, Torres-Cantero Alberto M
Division of Preventive Medicine and Public Health, University of Murcia School of Medicine, Espinardo (Murcia), IMIB-Arrixaca, Spain.
Department of Preventive Medicine, "Reina Sofia", University General Hospital, Murcia, Spain.
Prostate. 2017 Mar;77(4):406-411. doi: 10.1002/pros.23279. Epub 2016 Nov 16.
Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity.
We conducted a cross-sectional study with a total of 120 PCa patients with confirmed biopsy of the tumour from April 2007 to July 2015. Two variants of the anogenital distance were assessed, from the anus to the posterior base of the scrotum (AGD ) and to the cephalad insertion of the penis (AGD ). We compared differences in groups to evaluate the association between AGD measurements and severity of the preoperative biopsy and clinical scores.
Longer AGD was significantly associated with the highest Gleason score (P = 0.015) and D'Amico nomogram (P = 0.048). In contrast, no statistical differences were found in the AGD and severity of the preoperative biopsy.
These findings are consistent with the hypothesis that a higher prenatal androgen exposure is associated with higher severity of PCa. Prostate 77: 406-411, 2017. © 2016 Wiley Periodicals, Inc.
肛门生殖器距离（AGD），即从肛门中心到生殖器的距离，是哺乳动物的一种性二态性表型。实验研究表明，AGD是发育男性化时期产前雄激素暴露的生物标志物。本研究的目的是评估作为产前激素环境间接标志物的肛门生殖器距离（AGD）与前列腺癌（PCa）严重程度之间的关系。
我们进行了一项横断面研究，共纳入了2007年4月至2015年7月期间经肿瘤活检确诊的120例PCa患者。评估了肛门生殖器距离的两个变量，从肛门到阴囊后基部（AGD₁）以及到阴茎头端插入处（AGD₂）。我们比较了各组之间的差异，以评估AGD测量值与术前活检严重程度和临床评分之间的关联。
较长的AGD与最高Gleason评分（P = 0.015）和达米科列线图（P = 0.048）显著相关。相比之下，AGD与术前活检严重程度之间未发现统计学差异。
这些发现与产前雄激素暴露较高与PCa严重程度较高相关的假设一致。前列腺77: 406 - 411, 2017。© 2016威利期刊公司。
