Holdstein Y, Pratt H, Goldsher M, Rosen G, Shenhav R, Linn S, Mor A, Barkai A
J Laryngol Otol. 1986 Sep;100(9):1031-6. doi: 10.1017/s0022215100100519.
Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL clicks presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD(I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the peripheral portion of the auditory system with axonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.
对29名成人和儿童进行了听觉脑干诱发电位（ABEP）记录，这些人在本研究前约一年通过食物意外接触了铅。以10次/秒和55次/秒的速率呈现75 dBHL的点击声来记录ABEP。计算了峰潜伏期和峰间潜伏期差异的平均值。还计算了增加刺激速率的影响的平均值。为正常儿童和成人对照组计算了类似的值。IPLD（I-III）显示出最显著且反复出现的结果，与对照组相比，铅暴露儿童的峰间潜伏期更长。另一方面，增加刺激速率对成年铅暴露受试者的影响比对儿童的影响更大。这些结果可能意味着听觉系统外周部分存在轴突和髓鞘受累的损伤。ABEP被认为是亚临床铅暴露对神经系统影响的敏感检测指标。
