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英国引入选择性筛查对髋关节发育不良的流行病学、临床表现及治疗结果的影响。

The impact of the introduction of selective screening in the UK on the epidemiology, presentation, and treatment outcomes of developmental dysplasia of the hip.

作者信息

Poacher Arwel T, Hathaway Isaac, Crook Daniel L, Froud Joseph L J, Scourfield Lily, James Catherine, Horner Matthew, Carpenter Eleanor C

机构信息

Trauma Department, University Hospital of Wales, Cardiff, UK.

Cardiff University School of Medicine, Cardiff, UK.

出版信息

Bone Jt Open. 2023 Aug 23;4(8):635-642. doi: 10.1302/2633-1462.48.BJO-2022-0158.R1.

Abstract

AIMS

Developmental dysplasia of the hip (DDH) can be managed effectively with non-surgical interventions when diagnosed early. However, the likelihood of surgical intervention increases with a late presentation. Therefore, an effective screening programme is essential to prevent late diagnosis and reduce surgical morbidity in the population.

METHODS

We conducted a systematic review and meta-analysis of the epidemiological literature from the last 25 years in the UK. Articles were selected from databases searches using MEDLINE, EMBASE, OVID, and Cochrane; 13 papers met the inclusion criteria.

RESULTS

The incidence of DDH within the UK over the last 25 years is 7.3/1,000 live births with females making up 86% of the DDH population (odds ratio 6.14 (95% confidence interval 3.3 to 11.5); p < 0.001). The incidence of DDH significantly increased following the change in the Newborn and Infant Physical Examination (NIPE) guidance from 6.5/1,000 to 9.4/1,000 live births (p < 0.001). The rate of late presentation also increased following the changes to the NIPE guidance, rising from 0.7/1,000 to 1.2/1,000 live births (p < 0.001). However, despite this increase in late-presenting cases, there was no change in the rates of surgical intervention (0.8/1,000 live births; p = 0.940).

CONCLUSION

The literature demonstrates that the implementation of a selective screening programme increased the incidence of DDH diagnosis in the UK while subsequently increasing the rates of late presentation and failing in its goal of reducing the rates of surgical intervention for DDH.

摘要

目的

发育性髋关节发育不良(DDH)若早期诊断,可通过非手术干预有效治疗。然而,就诊延迟会增加手术干预的可能性。因此,有效的筛查计划对于预防延迟诊断和降低人群中的手术发病率至关重要。

方法

我们对英国过去25年的流行病学文献进行了系统综述和荟萃分析。通过使用MEDLINE、EMBASE、OVID和Cochrane数据库检索选取文章;13篇论文符合纳入标准。

结果

在英国,过去25年中DDH的发病率为每1000例活产中有7.3例,女性占DDH患者总数的86%(优势比6.14(95%置信区间3.3至11.5);p<0.001)。新生儿及婴儿体格检查(NIPE)指南变更后,DDH的发病率显著上升,从每1000例活产6.5例增至9.4例(p<0.001)。NIPE指南变更后,延迟就诊率也有所上升,从每1000例活产0.7例升至1.2例(p<0.001)。然而,尽管延迟就诊病例有所增加,但手术干预率并无变化(每1000例活产0.8例;p = 0.940)。

结论

文献表明,在英国实施选择性筛查计划增加了DDH的诊断率,同时随后增加了延迟就诊率,且未能实现降低DDH手术干预率的目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ef/10444535/004825aa9f3f/BJO-2022-0158.R1-galleyfig1.jpg

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