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人月经血来源的干细胞对多囊卵巢综合征影响的雌性大鼠卵巢卵泡发生、血管生成和胶原容积的作用。

The effect of human menstrual blood-derived stem cells on ovarian folliculogenesis, angiogenesis and collagen volume in female rats affected by the polycystic ovary syndrome.

机构信息

Anatomical Sciences Department, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

出版信息

J Ovarian Res. 2023 Aug 22;16(1):170. doi: 10.1186/s13048-023-01244-9.

DOI:10.1186/s13048-023-01244-9
PMID:37608312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10463952/
Abstract

BACKGROUND

Infertility is one of the common problems among couples, affecting millions of people worldwide. Polycystic ovary syndrome (PCOS) is one of the main causes of infertility in women and is associated with abnormal folliculogenesis, angiogenesis and fibrosis. Common treatments may lead to numerous adverse effects on the patient's quality of life. The present study aimed to investigate the effects of human menstrual blood-derived stem cells on the ovarian histology of a PCOS model of Wistar rats.

RESULTS

Based on the Papanicolaou test and H&E staining results, the number of primary, secondary and antral follicles in the PCOS and PCOS-Sham groups significantly increased compared to the control group, while they significantly decreased in the PCOS + Stem cells group compared to the PCOS and PCOS-Sham groups. Further, the number of atretic follicles in both PCOS and PCOS-Sham groups significantly increased in comparison with the control group and decreased in the PCOS + Stem cells group, compared to the two mentioned groups. Moreover, the Graafian follicles number was decreased in the PCOS and PCOS-Sham groups to significantly increase in the PCOS + Stem cells group. Based on Masson's trichrome staining, the number of blood vessels in PCOS and PCOS-Sham groups significantly increased compared to the control group, while a decrease was observed in the PCOS + Stem cells group, compared to PCOS and PCOS-Sham groups.

CONCLUSION

The administration of MenSCs improved folliculogenesis in rats with polycystic ovaries. Also, MenSCs could ameliorate PCOS symptoms by improving fibrosis as well as angiogenesis and weight gain.

摘要

背景

不孕是夫妇常见问题之一，影响全球数百万人。多囊卵巢综合征（PCOS）是女性不孕的主要原因之一，与异常卵泡发生、血管生成和纤维化有关。常见的治疗方法可能会对患者的生活质量产生许多不良反应。本研究旨在探讨人月经血源性干细胞对 Wistar 大鼠 PCOS 模型卵巢组织学的影响。

结果

根据巴氏涂片检查和 H&E 染色结果，PCOS 和 PCOS-Sham 组的初级、次级和窦卵泡数量与对照组相比显著增加，而 PCOS+Stem cells 组与 PCOS 和 PCOS-Sham 组相比则显著减少。此外，与对照组相比，PCOS 和 PCOS-Sham 组的闭锁卵泡数量显著增加，而 PCOS+Stem cells 组则减少。而且，PCOS 和 PCOS-Sham 组的格拉夫卵泡数量减少，而 PCOS+Stem cells 组则显著增加。根据 Masson 三色染色，PCOS 和 PCOS-Sham 组的血管数量与对照组相比显著增加，而 PCOS+Stem cells 组则减少，与 PCOS 和 PCOS-Sham 组相比。

结论

MenSCs 的给药改善了多囊卵巢大鼠的卵泡发生。此外，MenSCs 可以通过改善纤维化以及血管生成和体重增加来改善 PCOS 症状。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/8309d491358d/13048_2023_1244_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/9681741e9ae9/13048_2023_1244_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/e3e6683426fb/13048_2023_1244_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/d70892218afc/13048_2023_1244_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/01f96a474086/13048_2023_1244_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c3/10463952/d6ace454705d/13048_2023_1244_Fig13_HTML.jpg

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