经血来源干细胞接种的脱细胞人羊膜促进切除伤口修复。
Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane.
作者信息
Farzamfar Saeed, Salehi Majid, Ehterami Arian, Naseri-Nosar Mahdi, Vaez Ahmad, Zarnani Amir Hassan, Sahrapeyma Hamed, Shokri Mohammad-Reza, Aleahmad Mehdi
机构信息
1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
出版信息
Biomed Eng Lett. 2018 Sep 11;8(4):393-398. doi: 10.1007/s13534-018-0084-1. eCollection 2018 Nov.
Abstract
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 10 cells/cm and implanted onto a rat's 1.50 × 1.50 cm full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
摘要
这是第一项证明通过脱细胞人羊膜（DAM）进行月经血源性干细胞（MenSC）移植以促进皮肤切除伤口修复有效性的研究。将MenSCs以3×10个细胞/cm的密度接种到DAM上，并植入大鼠1.50×1.50 cm的全层切除伤口缺损处。伤口闭合和组织病理学检查结果表明，与DAM治疗相比，接种MenSCs的DAM能显著改善伤口愈合。总而言之，我们的数据表明，MenSCs可能是用于再生皮肤损伤的细胞疗法的潜在细胞来源。
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