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帕金森病中的吞咽困难:第一部分——病理生理学与诊断方法

Dysphagia in Parkinson Disease: Part I - Pathophysiology and Diagnostic Practices.

作者信息

Rudisch Denis Michael, Krasko Maryann N, Burdick Ryan, Broadfoot Courtney K, Rogus-Pulia Nicole, Ciucci Michelle R

机构信息

Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, 1300 University Ave, Madison, WI 53706, USA.

Department of Communication Sciences and Disorders, University of Wisconsin-Madison, 1975 Willow Drive, Madison, WI 53706, USA.

出版信息

Curr Phys Med Rehabil Rep. 2023 Jun;11(2):176-187. doi: 10.1007/s40141-023-00392-9. Epub 2023 Mar 28.


DOI:10.1007/s40141-023-00392-9
PMID:37608845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10441627/
Abstract

PURPOSE OF REVIEW: Dysphagia affects the majority of individuals with Parkinson disease (PD) and is not typically diagnosed until later in disease progression. This review will cover the current understanding of PD pathophysiology, and provides an overview of dysphagia in PD including diagnostic practices, gaps in knowledge, and future directions. RECENT FINDINGS: Many non-motor and other motor signs of PD appear in the prodrome prior to the manifestation of hall- mark signs and diagnosis. While dysphagia often presents already in the prodrome, it is not routinely addressed in standard neurology examinations. SUMMARY: Dysphagia in PD can result in compromised efficiency and safety of swallowing, which significantly contributes to malnutrition and dehydration, decrease quality of life, and increase mortality. The heterogeneous clinical presentation of PD complicates diagnostic procedures which often leads to delayed treatment. Research has advanced our knowledge of mechanisms underlying PD, but dysphagia is still largely understudied, especially in the prodromal stage.

摘要

综述目的:吞咽困难影响大多数帕金森病(PD)患者,且通常在疾病进展后期才被诊断出来。本综述将涵盖对PD病理生理学的当前理解,并概述PD中的吞咽困难,包括诊断方法、知识空白和未来方向。 最新发现:PD的许多非运动和其他运动症状在标志性症状出现和诊断之前的前驱期就已出现。虽然吞咽困难在前驱期就经常出现,但在标准神经科检查中并未常规涉及。 总结:PD中的吞咽困难会导致吞咽效率和安全性受损,这会显著导致营养不良和脱水,降低生活质量,并增加死亡率。PD的异质性临床表现使诊断程序复杂化,常常导致治疗延迟。研究增进了我们对PD潜在机制的了解,但吞咽困难仍在很大程度上未得到充分研究,尤其是在前驱期。

相似文献

[1]
Dysphagia in Parkinson Disease: Part I - Pathophysiology and Diagnostic Practices.

Curr Phys Med Rehabil Rep. 2023-6

[2]
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[3]
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[4]
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[5]
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[7]
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[9]
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[10]
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[3]
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[4]
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[5]
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[6]
Adherence of Clinical Practice Guidelines for Oropharyngeal Dysphagia in Parkinson Disease to Trustworthy Standards: A Systematic Survey.

Dysphagia. 2024-9-21

[7]
Vocal and tongue exercise in early to mid-stage Parkinson disease using the Pink1-/- rat.

Brain Res. 2024-8-15

本文引用的文献

[1]
Oral and gut dysbiosis leads to functional alterations in Parkinson's disease.

NPJ Parkinsons Dis. 2022-7-7

[2]
Dysphagia in Parkinson's disease: Pharyngeal manometry and fiberoptic endoscopic evaluation.

Auris Nasus Larynx. 2022-12

[3]
Salivation in Parkinson's disease: A scoping review.

Gerodontology. 2023-3

[4]
Six-Year Follow-Up of Dysphagia in Patients with Parkinson's Disease.

Dysphagia. 2022-10

[5]
Neuropathological evidence of body-first vs. brain-first Lewy body disease.

Neurobiol Dis. 2021-12

[6]
Evaluation of Spontaneous Swallow Frequency in Healthy People and Those With, or at Risk of Developing, Dysphagia: A Review.

Gerontol Geriatr Med. 2021-9-27

[7]
Parkinson's disease.

Lancet. 2021-6-12

[8]
Polypharmacy and saliva volumes in the northeast of Germany - The Study of Health in Pomerania.

Community Dent Oral Epidemiol. 2022-4

[9]
The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer's Disease and Parkinson's Disease.

Diagnostics (Basel). 2021-2-22

[10]
Oral Dysbiosis and Inflammation in Parkinson's Disease.

J Parkinsons Dis. 2021

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