Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Neurology, People's Hospital of Haining, Haining, Zhejiang, China.
Eur J Clin Nutr. 2018 Jan;72(1):82-86. doi: 10.1038/ejcn.2017.100. Epub 2017 Jul 12.
BACKGROUND/OBJECTIVES: Dysphagia is relatively common in patients with Parkinson disease (PD) and can have a negative impact on their quality of life; therefore, it is imperative that its prevalence in PD patients is studied. The aim of this study was to explore the prevalence and clinical correlation of dysphagia in Chinese PD patients.
SUBJECTS/METHODS: We recruited 116 Chinese PD patients. A videofluoroscopic study of swallowing (VFSS) was used to identify dysphagia. Assessments, including water drinking test, relative motor symptoms, non-motor symptoms (NMS) and quality of life, were performed to analyze the risks of dysphagia.
The prevalence of dysphagia was 87.1%. The comparison of demographic and clinical features between patients with and without dysphagia included sex, education level, disease course, Mini-mental State Examination (MMSE), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Question 6, 7 of the Unified Parkinson Disease Rating Scale (UPDRS Part II), Hoehn-Yahr stage (H&Y), water drinking test, 39-item Parkinson Disease Questionnaire (PDQ-39) and Non-Motor Symptoms Quest (NMSQ). We found significant correlations between dysphagia and age. Using age, disease course, and H&Y stage as the independent variable in our regression analysis for assessing the risk factors of dysphagia in PD patients, age and H&Y stage displayed a strong correlation as the risk factors. The risk of dysphagia in elderly PD patients is 1.078 times greater than that of younger PD patients. Also, the risk of dysphagia in PD patients of a greater H&Y staging is 3.260 times greater than that of lower staging PD patients.
Our results suggest that dysphagia is common in Chinese PD patients. Older patients or those in higher H&Y stages are more likely to experience dysphagia. There is no correlation between dysphagia and PD duration.
背景/目的：吞咽困难在帕金森病（PD）患者中较为常见，会对其生活质量产生负面影响；因此，研究 PD 患者吞咽困难的患病率势在必行。本研究旨在探讨中国 PD 患者吞咽困难的患病率及临床相关性。
我们招募了 116 名中国 PD 患者。使用视频荧光透视吞咽检查（VFSS）来确定吞咽困难。进行水饮测试、相对运动症状、非运动症状（NMS）和生活质量评估，以分析吞咽困难的风险。
吞咽困难的患病率为 87.1%。对有吞咽困难和无吞咽困难的患者的人口统计学和临床特征进行比较，包括性别、教育程度、病程、简易精神状态检查（MMSE）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、统一帕金森病评定量表（UPDRS 第二部分）的问题 6、7、Hoehn-Yahr 分期（H&Y）、水饮测试、帕金森病问卷（PDQ-39）和非运动症状问卷（NMSQ）。我们发现吞咽困难与年龄之间存在显著相关性。在我们的回归分析中，使用年龄、病程和 H&Y 分期作为评估 PD 患者吞咽困难危险因素的自变量，年龄和 H&Y 分期显示出较强的相关性，是危险因素。老年 PD 患者发生吞咽困难的风险是年轻 PD 患者的 1.078 倍。此外，H&Y 分期较高的 PD 患者发生吞咽困难的风险是 H&Y 分期较低的 PD 患者的 3.260 倍。
我们的结果表明，吞咽困难在中国 PD 患者中较为常见。年龄较大或 H&Y 分期较高的患者更容易出现吞咽困难。吞咽困难与 PD 病程无相关性。
