Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Medical Library, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
Gerodontology. 2023 Mar;40(1):26-38. doi: 10.1111/ger.12628. Epub 2022 Mar 4.
We aimed to provide an overview of the available literature that includes both objective assessments (namely hypersalivation and hyposalivation) and the subjective experience (namely xerostomia and drooling) of salivary problems in patients with Parkinson's disease.
In patients with Parkinson's disease, there may be complaints of salivary problems such as xerostomia or drooling. This can have consequences for their oral health and quality of life. To date, systematic reviews have focused on drooling only.
A literature search in 4 databases was performed up to 12 February 2021. Two researchers independently assessed studies for eligibility.
In total, 63 studies were included. The prevalence of self-reported xerostomia ranged from 49% to 77%, and that of self-reported drooling ranged from 5% to 80%. Ten articles reported a significantly lower mean salivary flow in patients with Parkinson's disease than in controls. None of the articles with both a control group and a patient group reported a significantly higher salivary flow in patients with Parkinson's disease. When questioned about subjective salivary problems, a significantly higher prevalence of both xerostomia (7 studies) and drooling (14 studies) was found in patients with Parkinson's disease than in controls. Patients with Parkinson's disease have a lower salivary flow rate and higher prevalence of both xerostomia and drooling than controls.
The complexity of salivary problems present in patients with Parkinson's disease necessitates a multidisciplinary approach in order to avoid mutually counteracting treatments from different healthcare professionals.
我们旨在提供对现有文献的概述，其中包括帕金森病患者的唾液问题的客观评估（即流涎过多和流涎过少）和主观体验（即口干和流口水）。
帕金森病患者可能会出现唾液问题的主诉，如口干或流口水。这会对他们的口腔健康和生活质量产生影响。迄今为止，系统评价仅集中在流涎上。
对 4 个数据库进行了文献检索，检索时间截至 2021 年 2 月 12 日。两名研究人员独立评估了研究的入选资格。
共纳入 63 项研究。自我报告的口干的患病率从 49%到 77%不等，自我报告的流口水的患病率从 5%到 80%不等。有 10 篇文章报道帕金森病患者的平均唾液流量明显低于对照组。在既有对照组又有患者组的文章中，没有一篇报道帕金森病患者的唾液流量明显更高。当被问及主观唾液问题时，帕金森病患者的口干（7 项研究）和流口水（14 项研究）的患病率均显著高于对照组。帕金森病患者的唾液流量较低，口干和流口水的患病率均高于对照组。
帕金森病患者的唾液问题复杂，需要多学科方法，以避免不同医疗保健专业人员的相互矛盾的治疗。
