Ahmed M E, Delbridge L, Le Quesne L P
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1002-6. doi: 10.1136/jnnp.49.9.1002.
Five standard, non-invasive tests of cardiovascular, autonomic function were performed in each of four groups of 30 subjects: controls, group 1, diabetics without clinical evidence of neuropathy; group 2, diabetics with neuropathy, but without foot ulceration; group 3, diabetics with neuropathic ulceration of the foot. The results showed a significant impairment of autonomic function in diabetics without clinically demonstrable somatic neuropathy compared with controls diabetics with somatic neuropathy compared with those without diabetics with neuropathic ulceration compared with those with neuropathy without ulceration. Parasympathetic function was more seriously affected than sympathetic. In patients who had only mild sensory neuropathy on clinical assessment, those with ulcers had significantly greater impairment of autonomic neuropathy compared with those with uncomplicated neuropathy.
对四组各30名受试者进行了五项标准的心血管自主神经功能无创测试：对照组；第1组，无神经病变临床证据的糖尿病患者；第2组，有神经病变但无足部溃疡的糖尿病患者；第3组，有足部神经病变性溃疡的糖尿病患者。结果显示，与对照组相比，无临床可证实的躯体神经病变的糖尿病患者自主神经功能有显著损害；与无躯体神经病变的糖尿病患者相比，有躯体神经病变的糖尿病患者自主神经功能有显著损害；与无溃疡的神经病变患者相比，有神经病变性溃疡的糖尿病患者自主神经功能有显著损害。副交感神经功能比交感神经功能受影响更严重。在临床评估仅有轻度感觉神经病变的患者中，有溃疡的患者与无并发症神经病变的患者相比，自主神经病变的损害明显更大。
