Faerman I, Faccio E, Calb I, Razumny J, Franco N, Dominguez A, Podestá H A
Diabetologia. 1982 Feb;22(2):96-9. doi: 10.1007/BF00254836.
In diabetics with the anhidrotic syndrome, autonomic nerve fibres were studied in skin biopsies using argentic techniques and light microscopy. The Minor test was used to differentiate normal from anhidrotic skin areas. In the anhidrotic areas, histology of the nerve fibres showed beading, spindle-shaped thickening and fragmentation adjacent to the sweat glands. These changes were similar to those observed in two patients who had previously undergone lumbar sympathectomy. No abnormalities of the sympathetic nerve endings could be found in biopsies taken from normal areas of the forearm of the same patients. We conclude that the diabetic anhidrotic syndrome, a form of diabetic autonomic neuropathy, is due to a lesion of the sympathetic nerve supply to the skin. It is suggested that the Minor test or a skin biopsy should be performed in diabetic patients who are being considered for surgical sympathectomy.
在患有无汗综合征的糖尿病患者中，采用银染技术和光学显微镜对皮肤活检组织中的自主神经纤维进行了研究。使用米诺试验来区分正常皮肤区域和无汗皮肤区域。在无汗区域，神经纤维的组织学表现为汗腺附近出现串珠样改变、纺锤形增粗和断裂。这些变化与之前接受过腰交感神经切除术的两名患者所观察到的变化相似。在同一患者前臂正常区域所取的活检组织中未发现交感神经末梢有异常。我们得出结论，糖尿病无汗综合征作为糖尿病自主神经病变的一种形式，是由于皮肤的交感神经供应受损所致。建议在考虑进行手术交感神经切除术的糖尿病患者中进行米诺试验或皮肤活检。
