Grover-Johnson N M, Baumann F G, Imparato A M, Kim G E, Thomas P K
Diabetologia. 1981;20(1):31-8. doi: 10.1007/BF00253813.
A quantitative ultrastructural analysis was made of the terminal innervation of epineurial arterioles in the sural nerve of 6 diabetic and 6 non-diabetic patients of comparable age (mean +/- SD: 68 +/- 9 non-diabetic, 65 +/- 16 diabetic) with end stage peripheral vascular disease. The results demonstrated specific differences, identifiable morphometrically, in the pattern of innervation of epineurial vessels of diabetics compared with non-diabetics. The differences were: 1) in the diabetic group the proportion of perivascular axons found less than 7 microns from the nearest smooth muscle cell was significantly less than in the non-diabetic group (p less than 0.001); 2) the mean distance of the axons from their effector sites, the vascular smooth muscle cells, was nearly twice as far in the diabetic group compared with the non-diabetic group (p less than 0.05); and 3) the mean absolute number of axons less than 7 microns from the arteriole in the diabetic group was significantly less than in the non-diabetic group (p less than 0.01). These results demonstrate that the neuropathy associated with diabetes mellitus also involves the autonomic terminal innervation of some blood vessels. In addition, this neuropathy selectively affects the vasomotor nerves closer than 7 microns to the media.
对6例患有终末期周围血管疾病、年龄相仿（平均±标准差：非糖尿病患者68±9岁，糖尿病患者65±16岁）的糖尿病患者和6例非糖尿病患者腓肠神经中神经外膜小动脉的终末神经支配进行了定量超微结构分析。结果显示，与非糖尿病患者相比，糖尿病患者神经外膜血管的神经支配模式存在形态学上可识别的特定差异。这些差异为：1）在糖尿病组中，距最近平滑肌细胞小于7微米的血管周围轴突比例显著低于非糖尿病组（p<0.001）；2）糖尿病组中轴突与其效应部位即血管平滑肌细胞的平均距离几乎是非糖尿病组的两倍（p<0.05）；3）糖尿病组中距小动脉小于7微米的轴突平均绝对数量显著低于非糖尿病组（p<0.01）。这些结果表明，与糖尿病相关的神经病变也涉及一些血管的自主终末神经支配。此外，这种神经病变选择性地影响距中膜小于7微米的血管运动神经。
