Alberta Respiratory Centre and Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Synergy Respiratory and Cardiac Care, Sherwood Park, AB, Canada.
Front Public Health. 2023 Aug 7;11:1235189. doi: 10.3389/fpubh.2023.1235189. eCollection 2023.
Although previous reports link exposure to insulating materials with an increased risk of mesothelioma and chronic respiratory diseases, studies evaluating their associations with the risk of coronary artery diseases (CAD) are lacking.
We aimed at evaluating the associations between exposure to insulating materials and the 10-year risk of CAD among insulators.
In this cross-sectional study, we recruited 643 adults (≥18 years), full-time insulators from the Local 110 Heat and Frost Insulators and Allied Workers Union in Edmonton, Alberta. We obtained demographic information, personal and family history, and job-exposure history, including experience (years) and types of exposure to insulating materials. Clinical profiling including Framingham risk scores (FRS) was assessed.
Of all insulators, 89% were men (mean ± SD age: 47 ± 12 years), 27% had a parental history of cardiac diseases, and 22% had a comorbid chronic respiratory disease. In total, 53% reported exposure to asbestos, while 61, 82, and 94% reported exposure to ceramic fibers, fiberglass, and mineral fibers, respectively. In single-exposure multivariable regression models adjusted for experience, marital status, and body mass index (BMI), asbestos was found to be associated with higher FRS (: 1.004; 95%CI: 0.003-2.00). The association remained consistent in multi-exposure models and a higher association was found between asbestos exposure and FRS among insulators with comorbid chronic respiratory disease.
Our study demonstrates that apart from cancer and chronic respiratory diseases, asbestos exposure may also have a cardiac effect, thus warranting the need for systematic surveillance to protect workers from the adverse effects of these materials.
尽管先前的报告表明接触绝缘材料与间皮瘤和慢性呼吸道疾病的风险增加有关，但评估其与冠心病（CAD）风险之间关联的研究尚缺乏。
我们旨在评估绝缘材料暴露与绝缘工患 CAD 的 10 年风险之间的关联。
在这项横断面研究中，我们招募了来自阿尔伯塔省埃德蒙顿的 Local 110 热和霜冻保温工人工会的 643 名成年（≥18 岁）全职保温工。我们获得了人口统计学信息、个人和家族病史以及工作暴露史，包括暴露年限和接触绝缘材料的类型。对临床特征进行了评估，包括 Framingham 风险评分（FRS）。
在所有保温工中，89%为男性（平均年龄±标准差：47±12 岁），27%有心血管疾病家族史，22%患有合并慢性呼吸道疾病。共有 53%的人报告接触过石棉，分别有 61%、82%和 94%的人报告接触过陶瓷纤维、玻璃纤维和矿物纤维。在单暴露多变量回归模型中，在校正了暴露年限、婚姻状况和体重指数（BMI）后，石棉与较高的 FRS 相关（:1.004；95%CI：0.003-2.00）。在多暴露模型中，这种关联仍然一致，并且在患有合并慢性呼吸道疾病的保温工中，石棉暴露与 FRS 之间的关联更为密切。
我们的研究表明，除了癌症和慢性呼吸道疾病之外，石棉暴露可能还会对心脏产生影响，因此需要进行系统监测，以保护工人免受这些材料的不良影响。
