• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一例大细胞非霍奇金淋巴瘤患者的无白血病性白细胞淤滞：伴有独特中枢神经系统受累的病例报告

Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement.

作者信息

Jain S, Kotasek D, Blumbergs P C, Sage R E

出版信息

J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1079-83. doi: 10.1136/jnnp.49.9.1079.

DOI:10.1136/jnnp.49.9.1079
PMID:3760899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1029019/
Abstract

A 52-year-old man with large cell non-Hodgkin's lymphoma developed a unique pattern of central nervous system involvement by lymphoma while in apparent systemic remission. Despite intermittent neurological episodes suggestive of CNS involvement by lymphoma no evidence of CNS lymphoma was found on repeated cerebrospinal fluid and brain CT scan examinations. At necropsy widespread occlusion of cerebral blood vessels by malignant lymphoid cells was observed with extensive tissue necrosis and haemorrhages. Leukaemic involvement of peripheral blood was not detected on repeated blood film examinations during life.

摘要

一名52岁的大细胞非霍奇金淋巴瘤患者在明显的全身缓解期出现了淋巴瘤累及中枢神经系统的独特模式。尽管间歇性神经发作提示淋巴瘤累及中枢神经系统，但多次脑脊液和脑部CT扫描检查均未发现中枢神经系统淋巴瘤的证据。尸检时观察到恶性淋巴细胞广泛阻塞脑血管，伴有广泛的组织坏死和出血。生前多次血液涂片检查均未检测到外周血白血病浸润。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/408033d550bb/jnnpsyc00101-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/189e7555f4d7/jnnpsyc00101-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/bfaf4b95a671/jnnpsyc00101-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/408033d550bb/jnnpsyc00101-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/189e7555f4d7/jnnpsyc00101-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/bfaf4b95a671/jnnpsyc00101-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5c/1029019/408033d550bb/jnnpsyc00101-0103-b.jpg

相似文献

1
Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement.一例大细胞非霍奇金淋巴瘤患者的无白血病性白细胞淤滞：伴有独特中枢神经系统受累的病例报告
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1079-83. doi: 10.1136/jnnp.49.9.1079.
2
The incidence of secondary central nervous system involvement in patients with non-Hodgkin's lymphoma as detected by 18F-FDG PET/CT.18F-FDG PET/CT检测非霍奇金淋巴瘤患者继发中枢神经系统受累的发生率。
Nucl Med Commun. 2013 Jan;34(1):50-6. doi: 10.1097/MNM.0b013e32835aaa48.
3
Characteristic features of malignant lymphoma with central nervous system involvement.
Surg Neurol. 2000 Feb;53(2):163-7. doi: 10.1016/s0090-3019(99)00186-x.
4
Intracerebral hemorrhage as a late complication after CNS treatment of childhood lymphoma.脑出血作为儿童淋巴瘤中枢神经系统治疗后的晚期并发症。
Klin Padiatr. 1998 Nov-Dec;210(6):406-8. doi: 10.1055/s-2008-1043912.
5
Non-Hodgkin's lymphoma presenting with isolated cauda equina compression.以孤立性马尾神经受压为表现的非霍奇金淋巴瘤。
Q J Med. 1987 Dec;65(248):1005-7.
6
Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma. Report of 2 cases.与非霍奇金淋巴瘤相关的恶性黑棘皮病。2例报告。
Dermatologica. 1988;176(3):133-7.
7
Richter syndrome and brain involvement: low-grade lymphoma relapsing as cerebral high-grade lymphoma.里希特综合征合并脑部受累：低级淋巴瘤复发为脑高级别淋巴瘤。
Acta Haematol. 2012;127(2):93-5. doi: 10.1159/000334068. Epub 2011 Dec 10.
8
[Non-Hodgkin's lymphoma in a patient with sarcoidosis (the sarcoidosis-lymphoma syndrome)].结节病患者的非霍奇金淋巴瘤（结节病 - 淋巴瘤综合征）
Rinsho Ketsueki. 1992 Aug;33(8):1066-70.
9
Secondary involvement of the central nervous system in malignant non-Hodgkin's lymphoma. A study of 30 cases in a series of 498 patients.恶性非霍奇金淋巴瘤中枢神经系统的继发性累及。498例患者中30例的研究。
Oncology. 1987;44(2):98-101. doi: 10.1159/000226454.
10
Importance of complete staging in non-Hodgkin's lymphoma presenting as a cerebral mass lesion.以脑肿块病变为表现的非霍奇金淋巴瘤中完整分期的重要性。
Cancer. 1996 Mar 1;77(5):827-33. doi: 10.1002/(sici)1097-0142(19960301)77:5<827::aid-cncr4>3.0.co;2-b.

本文引用的文献

1
A distinctive type of intracerebral hemorrhage associated with "blastic crisis" in patients with leukemia.
Cancer. 1960 Jan-Feb;13:146-54. doi: 10.1002/1097-0142(196001/02)13:1<146::aid-cncr2820130126>3.0.co;2-1.
2
Central nervous system involvement in non-Hodgkin's lymphoma: an analysis of 105 cases.非霍奇金淋巴瘤的中枢神经系统受累：105例分析。
Cancer. 1982 Feb 1;49(3):586-95. doi: 10.1002/1097-0142(19820201)49:3<586::aid-cncr2820490331>3.0.co;2-c.
3
Non-Hodgkin's lymphomas in leukemic phase: clinicopathologic correlations.
Am J Med. 1980 Nov;69(5):667-74. doi: 10.1016/0002-9343(80)90416-7.
4
CNS involvement in the non-Hodgkin's lymphomas.中枢神经系统受累于非霍奇金淋巴瘤。
Cancer. 1980 Feb;45(3):545-52. doi: 10.1002/1097-0142(19800201)45:3<545::aid-cncr2820450322>3.0.co;2-6.
5
Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma.非霍奇金淋巴瘤中的循环单克隆B淋巴细胞
N Engl J Med. 1984 Dec 6;311(23):1476-81. doi: 10.1056/NEJM198412063112304.
6
Central nervous system relapse in unfavourable-histology non-Hodgkin's lymphoma: is prophylaxis indicated?组织学类型不良的非霍奇金淋巴瘤中枢神经系统复发：是否需要进行预防？
Lancet. 1984 Sep 22;2(8404):685-7. doi: 10.1016/s0140-6736(84)91235-2.
7
Pathology of leukemia in the brain and meninges: postmortem studies of patients with acute leukemia and of mice given inoculations of L1210 leukemia.
Cancer Res. 1965 Oct;25(9):1555-71.
8
Report of the Committee on Hodgkin's Disease Staging Classification.霍奇金病分期分类委员会报告
Cancer Res. 1971 Nov;31(11):1860-1.
9
Lymphomatous leptomeningitis.淋巴瘤性柔脑膜病
Am J Med. 1971 Aug;51(2):200-8. doi: 10.1016/0002-9343(71)90239-7.
10
The spiral nerve bands of Fontana.丰塔纳螺旋神经束
Brain. 1972;95(1):1-20. doi: 10.1093/brain/95.1.1.