Nazarzadeh Zare Ehsan, Khorsandi Danial, Zarepour Atefeh, Yilmaz Hulya, Agarwal Tarun, Hooshmand Sara, Mohammadinejad Reza, Ozdemir Fatma, Sahin Onur, Adiguzel Sevin, Khan Haroon, Zarrabi Ali, Sharifi Esmaeel, Kumar Arun, Mostafavi Ebrahim, Kouchehbaghi Negar Hosseinzadeh, Mattoli Virgilio, Zhang Feng, Jucaud Vadim, Najafabadi Alireza Hassani, Khademhosseini Ali
School of Chemistry, Damghan University, Damghan, 36716-45667, Iran.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, United States.
Bioact Mater. 2023 Aug 10;31:87-118. doi: 10.1016/j.bioactmat.2023.08.002. eCollection 2024 Jan.
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications. The physicochemical and mechanical properties, biocompatibility, toxicity, and biodegradability of heparin are discussed. In addition, the applications of heparin-based materials in various biomedical fields, such as drug/gene delivery, tissue engineering, cancer therapy, and biosensors, are reviewed. Finally, challenges, opportunities, and future perspectives in preparing heparin-based materials are summarized.
肝素是一种带负电荷的多糖，具有不同的链长和一个亲水性主链。由于其迷人的化学和物理性质、无毒性、生物相容性和生物可降解性，肝素已被广泛应用于医学的不同领域，如心血管和血液学领域。这篇综述重点介绍了基于肝素设计材料用于各种生物医学应用的近期进展和未来发展。讨论了肝素的物理化学和机械性能、生物相容性、毒性和生物可降解性。此外，还综述了基于肝素的材料在各种生物医学领域的应用，如药物/基因递送、组织工程、癌症治疗和生物传感器。最后，总结了制备基于肝素的材料所面临的挑战、机遇和未来展望。
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