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Can antibiotic impregnated cement nail achieve both infection control and bony union in infected diaphyseal femoral non-unions?抗生素浸渍骨水泥钉能否实现感染性股骨干骨不连的感染控制与骨愈合?
Injury. 2017 Aug;48 Suppl 2:S66-S71. doi: 10.1016/S0020-1383(17)30497-7.
2
Custom-Made Antibiotic Cement Nails in Orthopaedic Trauma: Review of Outcomes, New Approaches, and Perspectives.骨科创伤中定制抗生素骨水泥钉:疗效、新方法及展望综述
Biomed Res Int. 2015;2015:387186. doi: 10.1155/2015/387186. Epub 2015 Oct 5.
3
Orthopaedic biofilm infections.骨科生物膜感染
Curr Orthop Pract. 2011 Nov;22(6):558-563. doi: 10.1097/BCO.0b013e318230efcf.
4
Outcome in patients with an infected nonunion of the long bones treated with a reinforced antibiotic bone cement rod.带增强型抗生素骨水泥棒治疗长骨感染性骨不连患者的结局。
J Orthop Trauma. 2012 Mar;26(3):184-8. doi: 10.1097/BOT.0b013e318225f77c.
5
A cadaver model evaluating femoral intramedullary reaming: a comparison between new reamer design (Pressure Sentinel) and a novel suction/irrigation reamer (RIA).评估股骨髓内扩孔的尸体模型:新型扩孔器设计(压力监测器)与新型抽吸/冲洗扩孔器(RIA)的比较。
Injury. 2010 Nov;41 Suppl 2:S38-42. doi: 10.1016/S0020-1383(10)70007-3.
6
Use of antibiotic cement-impregnated intramedullary nail in treatment of infected non-union of long bones.抗生素骨水泥浸润髓内钉在治疗长骨感染性骨不连中的应用。
Indian J Orthop. 2009 Oct;43(4):396-402. doi: 10.4103/0019-5413.55468.
7
Indications for antibiotic cement nails.抗生素骨水泥钉的适应证。
J Orthop Trauma. 2009 May-Jun;23(5 Suppl):S26-30. doi: 10.1097/BOT.0b013e31819f27aa.
8
Enhancement of antibiotic elution from acrylic bone cement.提高抗生素从丙烯酸骨水泥中的洗脱率。
J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):467-75. doi: 10.1002/jbm.b.31281.
9
Antibiotic cement-coated nails for the treatment of infected nonunions and segmental bone defects.抗生素骨水泥涂层髓内钉治疗感染性骨不连和节段性骨缺损
J Bone Joint Surg Am. 2008 Nov;90 Suppl 4:163-74. doi: 10.2106/JBJS.H.00753.
10
Antibiotic cement-coated interlocking nail for the treatment of infected nonunions and segmental bone defects.抗生素骨水泥涂层交锁髓内钉治疗感染性骨不连和节段性骨缺损
J Orthop Trauma. 2007 Apr;21(4):258-68. doi: 10.1097/BOT.0b013e31803ea9e6.

骨水泥珠与骨水泥间隔物:适应证、技术及临床结果

Cement beads and cement spacers: indications, techniques, and clinical results.

作者信息

Kulkarni Govind Shivram, Kulkarni Sunil, Babhulkar Sushrut

机构信息

GSK Orthopedic and Trauma Institute.

GSKs Fracture and Orthopedic Hospital, PG Institute of Swasthiyog Pratishthan, Miraj.

出版信息

OTA Int. 2021 Jun 15;4(3 Suppl). doi: 10.1097/OI9.0000000000000118. eCollection 2021 Jun.

DOI:10.1097/OI9.0000000000000118
PMID:37609476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10441671/
Abstract

OBJECTIVES

To report our experience on the use of antibiotic coated nails (ACN) and cement beads for the management of bone infections.

MATERIALS AND METHODS

Infected nonunion (INU) cases were classified as: Type I (mild infection with no gap), Type II (moderate with good alignment, severe infection, gap <3 cm, no deformity), Type III (severe infection with gap ≥3 cm, deformity and limb shortening). Treatment involved either the insertion of ACN and cast (Type I), insertion of ACN, beads and external fixator (Type II), or Ilizarov methodology (Type III). A subset of 28 open fractures were admitted with severe contamination or delayed presentation with established infection and treated with debridement, ACN insertion, and antibiotic beads placed in soft tissue dead space areas.

RESULTS

Results of 133 cases were classified excellent, good, and poor. Type I INU reported 40 excellent and 22 good results. Type II INU reported 28 (39%) excellent, 30 (43%) good, and 13 (18%) poor results. Poor results were due to uncontrolled infection and knee stiffness. Three patients required knee fusion and 1 required amputation. Fracture union was reported in 68 cases. Four of the 28 Gustilo grade III open fractures treated with ACN developed infected nonunion and had poor function caused by stiff knees.

CONCLUSIONS

An antibiotic impregnated cement nail (ACN) fills the dead space and elutes high concentrations of antibiotics providing some mechanical stability. We recommend the adjunct use of an ACN for the management of INU cases and for use in select cases of Gustilo grade III open fractures.

摘要

目的

报告我们使用抗生素涂层钉(ACN)和骨水泥珠治疗骨感染的经验。

材料与方法

感染性骨不连(INU)病例分为:I型(轻度感染且无间隙)、II型(中度感染且对线良好、重度感染、间隙<3厘米、无畸形)、III型(重度感染且间隙≥3厘米、畸形和肢体短缩)。治疗方法包括插入ACN并使用石膏(I型)、插入ACN、骨水泥珠和外固定架(II型)或伊利扎罗夫技术(III型)。28例开放性骨折患者因严重污染或就诊延迟且已发生感染而入院,接受清创、插入ACN以及在软组织死腔区域放置抗生素骨水泥珠治疗。

结果

133例患者的结果分为优、良和差。I型INU报告40例优和22例良的结果。II型INU报告28例(39%)优、30例(43%)良和13例(18%)差的结果。差的结果是由于感染控制不佳和膝关节僵硬。3例患者需要膝关节融合,1例需要截肢。68例报告骨折愈合。28例接受ACN治疗的Gustilo III级开放性骨折中有4例发生感染性骨不连,且因膝关节僵硬导致功能差。

结论

抗生素浸渍骨水泥钉(ACN)可填充死腔并洗脱高浓度抗生素,提供一定的机械稳定性。我们建议在治疗INU病例以及部分Gustilo III级开放性骨折病例中辅助使用ACN。