Kulkarni Govind Shivram, Kulkarni Sunil, Babhulkar Sushrut
GSK Orthopedic and Trauma Institute.
GSKs Fracture and Orthopedic Hospital, PG Institute of Swasthiyog Pratishthan, Miraj.
OTA Int. 2021 Jun 15;4(3 Suppl). doi: 10.1097/OI9.0000000000000118. eCollection 2021 Jun.
To report our experience on the use of antibiotic coated nails (ACN) and cement beads for the management of bone infections.
Infected nonunion (INU) cases were classified as: Type I (mild infection with no gap), Type II (moderate with good alignment, severe infection, gap <3 cm, no deformity), Type III (severe infection with gap ≥3 cm, deformity and limb shortening). Treatment involved either the insertion of ACN and cast (Type I), insertion of ACN, beads and external fixator (Type II), or Ilizarov methodology (Type III). A subset of 28 open fractures were admitted with severe contamination or delayed presentation with established infection and treated with debridement, ACN insertion, and antibiotic beads placed in soft tissue dead space areas.
Results of 133 cases were classified excellent, good, and poor. Type I INU reported 40 excellent and 22 good results. Type II INU reported 28 (39%) excellent, 30 (43%) good, and 13 (18%) poor results. Poor results were due to uncontrolled infection and knee stiffness. Three patients required knee fusion and 1 required amputation. Fracture union was reported in 68 cases. Four of the 28 Gustilo grade III open fractures treated with ACN developed infected nonunion and had poor function caused by stiff knees.
An antibiotic impregnated cement nail (ACN) fills the dead space and elutes high concentrations of antibiotics providing some mechanical stability. We recommend the adjunct use of an ACN for the management of INU cases and for use in select cases of Gustilo grade III open fractures.
报告我们使用抗生素涂层钉(ACN)和骨水泥珠治疗骨感染的经验。
感染性骨不连(INU)病例分为:I型(轻度感染且无间隙)、II型(中度感染且对线良好、重度感染、间隙<3厘米、无畸形)、III型(重度感染且间隙≥3厘米、畸形和肢体短缩)。治疗方法包括插入ACN并使用石膏(I型)、插入ACN、骨水泥珠和外固定架(II型)或伊利扎罗夫技术(III型)。28例开放性骨折患者因严重污染或就诊延迟且已发生感染而入院,接受清创、插入ACN以及在软组织死腔区域放置抗生素骨水泥珠治疗。
133例患者的结果分为优、良和差。I型INU报告40例优和22例良的结果。II型INU报告28例(39%)优、30例(43%)良和13例(18%)差的结果。差的结果是由于感染控制不佳和膝关节僵硬。3例患者需要膝关节融合,1例需要截肢。68例报告骨折愈合。28例接受ACN治疗的Gustilo III级开放性骨折中有4例发生感染性骨不连,且因膝关节僵硬导致功能差。
抗生素浸渍骨水泥钉(ACN)可填充死腔并洗脱高浓度抗生素,提供一定的机械稳定性。我们建议在治疗INU病例以及部分Gustilo III级开放性骨折病例中辅助使用ACN。