Kanakaris Nikolaos K, Giannoudis Peter V
Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds.
NIHR Leeds Biomedical Research Center, Chapel Allerton Hospital, Leeds, United Kingdom.
OTA Int. 2021 Jun 15;4(3 Suppl). doi: 10.1097/OI9.0000000000000107. eCollection 2021 Jun.
Biofilm represents an organized multicellular community of bacteria having a complex 3D structure, formed by bacterial cells and their self-produced extracellular matrix. It usually attaches to any foreign body or fixation implant. It acts as a physical protective barrier of the bacteria from the penetration of antibodies, bacteriophages, granulocytes and biocides, antiseptics, and antibiotics. Biofilm-related infections will increase in the near future. This group of surgical site infections is the most difficult to diagnose, to suppress, to eradicate, and in general to manage. Multispecialty teams involved in all stages of care are an effective way to improve results and save resources and time for the benefit of patients and the health system. Significant steps have occurred recently in the prevention and development of clever tools that we can employ in this everlasting fight with the bacteria. Herein, we attempt to describe the nature and role of the "biofilm" to the specific clinical setting of surgical site infections in the field of orthopaedic trauma surgery.
生物膜代表由细菌细胞及其自身产生的细胞外基质形成的具有复杂三维结构的有组织的多细胞细菌群落。它通常附着在任何异物或固定植入物上。它作为细菌的物理保护屏障，可防止抗体、噬菌体、粒细胞以及杀菌剂、防腐剂和抗生素的渗透。与生物膜相关的感染在不久的将来将会增加。这类手术部位感染是最难诊断、抑制、根除以及总体管理的。参与护理各个阶段的多专业团队是改善治疗效果、节省资源和时间以造福患者和卫生系统的有效途径。最近在预防和开发我们可用于这场与细菌的持久斗争的智能工具方面已经取得了重大进展。在此，我们试图描述“生物膜”在骨科创伤手术领域手术部位感染的特定临床环境中的性质和作用。
