Ciolac Dumitru, Racila Renata, Duarte Carolina, Vasilieva Maria, Manea Diana, Gorincioi Nadejda, Condrea Alexandra, Crivorucica Igor, Zota Eremei, Efremova Daniela, Crivorucica Veaceslav, Ciocanu Mihail, Movila Alexandru, Groppa Stanislav A
Department of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.
Department of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy, 2004 Chisinau, Moldova.
Biomedicines. 2021 Nov 19;9(11):1730. doi: 10.3390/biomedicines9111730.
Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt-Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19.
全身炎症以及与某些病毒感染相关的宿主免疫反应可能会加速克雅氏病（CJD）患者的神经退行性变速度，克雅氏病是一种罕见的、可传播的神经退行性疾病。然而，新出现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对克雅氏病发病机制的影响尚不清楚。在本研究中，我们描述了一例散发性克雅氏病老年女性患者的病例，该患者在感染SARS-CoV-2和严重冠状病毒病2019（COVID-19）后出现癫痫发作，临床病情恶化，影像学显示神经退行性进展。尽管努力控制疾病进展，但结果仍令人沮丧。本报告进一步证明了SARS-CoV-2感染的年龄依赖性神经学效应，并提出了COVID-19后对克雅氏病的易感性及克雅氏病进展加快的情况。
