Dai Bingqing, Xin Yu, Jun Wang
Department of Dermatology, Yijishan Hospital Affiliated WithWannan Medical College, No. 2 ZheshanWest Road, Wuhu, Anhui, China.
Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
Arch Dermatol Res. 2025 Feb 1;317(1):322. doi: 10.1007/s00403-025-03836-5.
Primary Sjögren's Syndrome (PSS) and psoriasis are frequently observed to co-occur in clinical settings. However, the causal associations and underlying mechanisms between PSS and psoriasis remain poorly defined. In this study, we conducted bidirectional MR analysis to explore the causal relationship between PSS and psoriasis using four MR methods: inversevariance weighted, MR-Egger regression, weighted median, and weighted mode. Sensitivity analyses were carried out, employing different models and testing methods for comparison to assess the influence of heterogeneity and pleiotropy on our findings and to confirm the robustness of these results. We primarily employed the Inverse Variance Weighting (IVW) method for our analysis. A p-value of less than 0.05 indicates a significant causal relationship, while a p-value greater than 0.05 suggests the absence of such a relationship. The IVW analysis confirmed a causal relationship between psoriasis and primary Sjögren's syndrome (PSS) (OR: 3.149E-10, 95% CI 1.114E-18-0.089, P = 0.028), with the weighted median yielding similar results. Conversely, there was no causal association found between PSS and the risk of developing psoriasis (OR: 1.000, 95% CI 0.999-1.000, P = 0.328). This study reveals a causal relationship between primary Sjögren's syndrome (PSS) and psoriasis, demonstrating that psoriasis increases the risk of developing PSS, while the reverse is not true. This potential causal link offers new insights into the etiology of both PSS and psoriasis.
原发性干燥综合征（PSS）和银屑病在临床环境中经常同时出现。然而，PSS与银屑病之间的因果关联和潜在机制仍不明确。在本研究中，我们使用四种孟德尔随机化（MR）方法进行双向MR分析，以探讨PSS与银屑病之间的因果关系：逆方差加权法、MR-Egger回归法、加权中位数法和加权模式法。进行了敏感性分析，采用不同的模型和检验方法进行比较，以评估异质性和多效性对我们研究结果的影响，并确认这些结果的稳健性。我们主要采用逆方差加权（IVW）方法进行分析。p值小于0.05表示存在显著的因果关系，而p值大于0.05则表明不存在这种关系。IVW分析证实了银屑病与原发性干燥综合征（PSS）之间存在因果关系（比值比：3.149E-10，95%置信区间1.114E-18 - 0.089，P = 0.028），加权中位数法得出了类似结果。相反，未发现PSS与患银屑病风险之间存在因果关联（比值比：1.000，95%置信区间0.999 - 1.000，P = 0.328）。本研究揭示了原发性干燥综合征（PSS）与银屑病之间的因果关系，表明银屑病会增加患PSS的风险，反之则不成立。这种潜在的因果联系为PSS和银屑病的病因学提供了新的见解。
