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猫眼部低温期间视网膜温度的主动防御

Active defence of retinal temperature during hypothermia of the eye in cats.

作者信息

Stiehl W L, González-Lima F, Carrera A, Cuebas L M, Díaz R E

出版信息

J Physiol (Paris). 1986;81(1):26-33.

PMID:3761203
Abstract

The first objective was to determine how large changes in externally applied cooling influence intraocular temperature. The second objective was to determine whether vasoactive changes in the choroidal circulation influence retinal temperature. Temperature in the conjunctiva was decreased down to 6 degrees C by direct cooling of the cat's eye and the temperatures along the visual axis were measured with thermocouple probes. Temperature in the retina was maintained fairly constant showing thus an active resistance to cooling of the eye, but temperatures in the anterior chamber and lens were dependent on external temperature changes. Administration of vasoconstrictor drugs in the retrobulbar space resulted in drop of retinal temperature presumably by reducing choroidal blood flow during eye cooling. The experiments showed that the eye is provided with vasoactive mechanisms that allow temperature preservation in critical areas, such as the retina, even in the presence of extreme temperature changes. However, other ocular regions show passive resistance to cooling of the eye.

摘要

第一个目标是确定外部施加的冷却的大幅变化如何影响眼内温度。第二个目标是确定脉络膜循环中的血管活性变化是否影响视网膜温度。通过直接冷却猫眼,结膜温度降至6摄氏度,并用热电偶探头测量沿视轴的温度。视网膜温度保持相当恒定,因此显示出对眼睛冷却的主动抵抗,但前房和晶状体的温度取决于外部温度变化。在球后间隙给予血管收缩药物可能会通过在眼部冷却期间减少脉络膜血流而导致视网膜温度下降。实验表明,眼睛具有血管活性机制,即使在存在极端温度变化的情况下,也能在关键区域(如视网膜)保持温度。然而,眼睛的其他区域对眼睛冷却表现出被动抵抗。

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引用本文的文献

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Neural control of choroidal blood flow.脉络膜血流的神经控制。
Prog Retin Eye Res. 2018 May;64:96-130. doi: 10.1016/j.preteyeres.2017.12.001. Epub 2017 Dec 8.
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Cold Shock Proteins Are Expressed in the Retina Following Exposure to Low Temperatures.暴露于低温后,冷休克蛋白在视网膜中表达。
PLoS One. 2016 Aug 24;11(8):e0161458. doi: 10.1371/journal.pone.0161458. eCollection 2016.
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Authors' response.作者回复。
Indian J Ophthalmol. 2015 Dec;63(12):930-1.