Department of Biochemistry and Pharmacology, Discipline of Biochemistry, University of Medicine and Pharmacy "Victor Babes", E Murgu Square no.2, 300041, Timisoara, Romania.
Doctoral School, University of Medicine and Pharmacy "Victor Babes", E Murgu Square no.2, 300041, Timisoara, Romania.
Sci Rep. 2023 Aug 23;13(1):13806. doi: 10.1038/s41598-023-40754-w.
Predicting the clinical course of Covid-19 is a challenging task, given the multi-systemic character of the disease and the paucity of minimally invasive biomarkers of disease severity. Here, we evaluated the early (first two days post-admission) level of circulating hsa-miR-195-5p (miR-195, a known responder to viral infections and SARS-CoV-2 interactor) in Covid-19 patients and assessed its potential as a biomarker of disease severity. We show that plasma miR-195 correlates with several clinical and paraclinical parameters, and is an excellent discriminator between the severe and mild forms of the disease. Our Gene Ontology analysis of miR-195 targets differentially expressed in Covid-19 indicates a strong impact on cardiac mitochondria homeostasis, suggesting a possible role in long Covid and chronic fatigue syndrome (CFS) syndromes.
预测新冠病毒（Covid-19）的临床病程是一项极具挑战性的任务，因为该疾病具有多系统特征，且缺乏疾病严重程度的微创生物标志物。在此，我们评估了新冠病毒患者入院后最初两天（即早期）的循环 hsa-miR-195-5p（miR-195，一种已知的病毒感染应答物和 SARS-CoV-2 相互作用物）水平，并评估了其作为疾病严重程度生物标志物的潜力。我们发现，血浆 miR-195 与多项临床和临床前参数相关，且是区分疾病严重程度和轻度程度的优秀判别物。我们对新冠病毒患者中差异表达的 miR-195 靶基因的基因本体分析表明，其对心脏线粒体动态平衡具有强烈影响，这表明其可能与长新冠和慢性疲劳综合征（CFS）综合征有关。
