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微小RNA与新型冠状病毒肺炎并发症之间的关系。

The relationship between microRNAs and COVID-19 complications.

作者信息

Kebriaei Abdollah, Besharati Reza, Namdar Ahmad Abad Hasan, Havakhah Shahrzad, Khosrojerdi Mahsa, Azimian Amir

机构信息

Department of Pathobiology and Laboratory Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Department of Physiology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

出版信息

Noncoding RNA Res. 2024 Aug 22;10:16-24. doi: 10.1016/j.ncrna.2024.08.007. eCollection 2025 Feb.

Abstract

Over the past three years, since the onset of COVID-19, several scientific studies have concentrated on understanding susceptibility to the virus, the progression of the illness, and possible long-term complexity. COVID-19 is broadly recognized with effects on multiple systems in the body, and various factors related to society, medicine, and genetics/epigenetics may contribute to the intensity and results of the disease. Additionally, a infection can activate pathological activities and expedite the emergence of existing health issues into clinical problems. Forming easily accessible, distinctive, and permeable biomarkers is essential for categorizing patients, preventing the disease, predicting its course, and tailoring treatments for COVID-19 individually. One promising candidate for such biomarkers is microRNAs, which could serve various purposes in understanding diverse forms of COVID-19, including susceptibility, intensity, disease progression, outcomes, and potential therapeutic options. This review provides an overview of the most significant findings related to the involvement of microRNAs in COVID-19 pathogenesis. Furthermore, it explores the function of microRNAs in a broad span of effects that may arise from accompanying or underlying health status. It underscores the value of comprehending how diverse conditions, such as neurological disorders, diabetes, cardiovascular diseases, and obesity, interact with COVID-19.

摘要

在过去三年里,自新冠疫情爆发以来,多项科学研究集中于了解对该病毒的易感性、疾病进展以及可能出现的长期复杂性。新冠病毒对人体多个系统的影响已得到广泛认可,与社会、医学以及遗传学/表观遗传学相关的各种因素可能会影响该疾病的严重程度和结果。此外,感染会激活病理活动,并加速现有健康问题演变为临床问题。形成易于获取、独特且具有渗透性的生物标志物对于新冠患者的分类、疾病预防、病程预测以及个性化治疗方案的制定至关重要。此类生物标志物的一个有前景的候选者是微小RNA,它在理解新冠病毒的多种表现形式(包括易感性、严重程度、疾病进展、结果以及潜在治疗选择)方面具有多种用途。本综述概述了与微小RNA参与新冠病毒发病机制相关的最重要研究结果。此外,它还探讨了微小RNA在伴随或潜在健康状况可能产生的广泛影响中的作用。它强调了理解诸如神经疾病、糖尿病、心血管疾病和肥胖症等多种状况如何与新冠病毒相互作用的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/257b/11406673/58e21893d6ce/gr1.jpg

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