Bateman Grant Alexander, Bateman Alexander Robert
Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW, Australia.
Newcastle University Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia.
NPJ Microgravity. 2024 Feb 28;10(1):23. doi: 10.1038/s41526-024-00365-9.
Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. Previously, the current authors have discussed the similarities and differences between SANS and idiopathic intracranial hypertension to try to elucidate a possible pathophysiology. Recently, a theory has been advanced that SANS may occur secondary to failure of the glymphatic system caused by venous dilatation within the brain and optic nerves. There is recent evidence to suggest glymphatic obstruction occurs in childhood hydrocephalus, multiple sclerosis and syringomyelia due to venous outflow dilatation similar to that proposed in SANS. The purpose of the current paper is to discuss the similarities and differences between the known CSF and venous pathophysiology in SANS with these other terrestrial diseases, to see if they can shed any further light on the underlying cause of this microgravity-induced disease.
航天相关神经-眼部综合征（SANS）会在长期太空飞行期间改变宇航员的视力。此前，本文作者曾探讨过SANS与特发性颅内高压之间的异同，试图阐明可能的病理生理学机制。最近，有一种理论认为，SANS可能继发于脑和视神经内静脉扩张导致的类淋巴系统功能衰竭。最近有证据表明，由于静脉流出道扩张，儿童脑积水、多发性硬化症和脊髓空洞症中会发生类淋巴系统梗阻，这与SANS中提出的情况类似。本文的目的是讨论SANS中已知的脑脊液和静脉病理生理学与这些其他地球疾病之间的异同，看看它们是否能进一步揭示这种微重力诱发疾病的潜在病因。
