Harrington R M, Shertzer H G, Bercz J P
J Toxicol Environ Health. 1986;19(2):235-42. doi: 10.1080/15287398609530923.
In a previous study from this laboratory, chlorine dioxide (ClO2) treated drinking water depressed thyroxine (T4) levels in the African green monkey. The present study again demonstrated a decrease in T4 levels in the same species after 4 wk of oral exposure. However, after 8 wk of treatment T4 levels rebounded to above pretreatment levels, coinciding with an increase in thyroid radioiodide uptake. This T4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T4 levels dropped during the 8-wk ClO2 treatment period in a dose-dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO2 may have an effect on thyroid function in both species.
在本实验室先前的一项研究中，二氧化氯（ClO2）处理过的饮用水会降低非洲绿猴体内的甲状腺素（T4）水平。本研究再次表明，在口服暴露4周后，同一物种的T4水平有所下降。然而，在治疗8周后，T4水平反弹至预处理水平以上，同时甲状腺放射性碘摄取增加。这种T4反弹现象和碘摄取增加可能是由于一种代偿性内分泌机制。在大鼠中，T4水平在8周的ClO2治疗期间呈剂量依赖性下降，且未观察到反弹效应。大鼠的碘摄取值未受影响。看来ClO2可能对这两个物种的甲状腺功能都有影响。
