Orme J, Taylor D H, Laurie R D, Bull R J
J Toxicol Environ Health. 1985;15(2):315-22. doi: 10.1080/15287398509530657.
Chlorine dioxide (ClO2), an alternative to chlorine for drinking water disinfection, has been implicated as a potential antithyroid agent (Bercz et al., 1982). Because antithyroid compounds are known to alter neurobehavioral development, the present study was designed to determine if perinatal exposure to ClO2 affects behavioral activity in rat pups. The activity cage system was designed to monitor the development of locomotor activity of a litter of pups between ages 14-21 d. Pups were exposed to ClO2 either directly, by gavaging 14 mg/kg . from age 5 to 20 d, or indirectly via their dams' drinking water in concentrations of 2, 20, or 100 mg/l from gestation to weaning (21 d postpartum). Although the activity of the indirectly exposed group was not different from controls, the gavaged group showed significantly depressed activity for d 18 and 19 postpartum. The T4 levels of the 21-d-old pups was significantly depressed in the 100-mg/l ClO2 group. The gavaged pups showed an even greater T4 depression, which correlates with their activity levels. These data support the hypothesis that ClO2 affects thyroid function and suggests that a slight depression in T4 can result in developmental delays.
二氧化氯（ClO2）作为饮用水消毒中氯的替代品，被认为是一种潜在的抗甲状腺剂（Bercz等人，1982年）。由于已知抗甲状腺化合物会改变神经行为发育，本研究旨在确定围产期接触ClO2是否会影响幼鼠的行为活动。活动笼系统旨在监测一窝幼鼠在14至21日龄之间运动活动的发育情况。幼鼠在5至20日龄时通过灌胃14毫克/千克直接接触ClO2，或在从妊娠到断奶（产后21天）期间通过其母鼠的饮用水间接接触浓度为2、20或100毫克/升的ClO2。虽然间接接触组的活动与对照组没有差异，但灌胃组在产后第18天和第19天的活动明显降低。在100毫克/升ClO2组中，21日龄幼鼠的T4水平显著降低。灌胃幼鼠的T4降低更为明显，这与其活动水平相关。这些数据支持ClO2影响甲状腺功能的假设，并表明T4的轻微降低会导致发育延迟。
