补充亚麻籽油可增强抗氧化能力并减轻氧化应激：一项随机对照试验的系统评价和荟萃分析
Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
作者信息
Musazadeh Vali, Jafarzadeh Jaber, Keramati Majid, Zarezadeh Meysam, Ahmadi Mahshid, Farrokhian Zohreh, Ostadrahimi Alireza
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Evid Based Complement Alternat Med. 2021 Sep 3;2021:4438613. doi: 10.1155/2021/4438613. eCollection 2021.
OBJECTIVE
Studies have reported controversial findings regarding the flaxseed oil effect on antioxidant status biomarkers. The present meta-analysis aimed to determine the impact of flaxseed oil on the serum level of biomarkers of oxidative stress.
METHODS
A systematic search was conducted up to November 2020 on PubMed, Embase, Web of Science, Scopus, and Cochrane Central Library. Random-effects model was employed to perform meta-analysis. Subgroup analysis was carried out to determine the effect across different ranges of dosages and durations.
RESULTS
Eight trials were included with a total sample size of 429 individuals with a mean age range of 25 to 70 years. The results indicated that flaxseed oil supplementation led to a significant decrease in malondialdehyde (MDA) levels (SMD: -0.52 mol/L; 95% CI: -0.89, -0.15; =0.006, = 71.3, < 0.001) and increase in total antioxidant capacity (TAC) levels (WMD: 82.84 mmol/L; 95% CI: 19.80, 145.87; =0.006, = 92.7, < 0.001). No significant effect was observed on glutathione (GSH).
CONCLUSION
Our findings revealed that flaxseed oil supplementation might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults.
目的
关于亚麻籽油对抗氧化状态生物标志物的影响，已有研究报道了相互矛盾的结果。本荟萃分析旨在确定亚麻籽油对氧化应激生物标志物血清水平的影响。
方法
截至2020年11月，在PubMed、Embase、Web of Science、Scopus和Cochrane中央图书馆进行了系统检索。采用随机效应模型进行荟萃分析。进行亚组分析以确定不同剂量范围和持续时间的影响。
结果
纳入八项试验，总样本量为429人，平均年龄范围为25至70岁。结果表明，补充亚麻籽油导致丙二醛（MDA）水平显著降低（标准化均数差：-0.52μmol/L；95%置信区间：-0.89，-0.15；P=0.006，I²=71.3，P<0.001），总抗氧化能力（TAC）水平升高（加权均数差：82.84mmol/L；95%置信区间：19.80，145.87；P=0.006，I²=92.7，P<0.001）。未观察到对谷胱甘肽（GSH）有显著影响。
结论
我们的研究结果表明，补充亚麻籽油可能在增强成年人抗氧化防御系统和改善氧化应激方面发挥有益作用。
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