一种在中国和土耳其流行的牛病毒性腹泻病毒 1 型的种基因型。
A Bovine viral diarrhea virus type 1 species genotypes circulating in China and Turkey.
机构信息
Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, People's Republic of China.
出版信息
Open Vet J. 2023 Jul;13(7):903-931. doi: 10.5455/OVJ.2023.v13.i7.12. Epub 2023 Jul 31.
BACKGROUND
A Bovine viral diarrhea virus type 1 (BVDV-1) is a heterogeneous species within the genus, affecting cattle and other ruminants, with economic impact on livestock production.
AIM
The study aimed to update the taxonomy of the A, BVDV-1 species and to verify the clustering of the strains reported as genotype 1v, originating from different countries.
METHODS
Recently deposited strains from China, Turkey, and Iran have been evaluated by the palindromic nucleotide substitutions (PNS) genotyping method.
RESULTS
Based on secondary structure analysis of the 5'-UTR sequences, strains reported as 1v from China were clustered as sub genotype 1.7.3 (1o). Genotype 1.19 (1w) was restricted to China and genotype 1.21 (1v) was present only in Turkey and Iran.
CONCLUSION
The application of the PNS method clarified the taxonomical status of strains, revealing the homonymy of genetically different clusters. Furthermore, these observations indicated geographic segregation in the A species, and confirmed the occurrence of new atypical genetic variants, with potential implications on control and prophylaxis.
背景
牛病毒性腹泻病毒 1 型（BVDV-1）是属内的一个异质物种，感染牛和其他反刍动物，对畜牧业生产造成经济影响。
目的
本研究旨在更新 A 种、BVDV-1 种的分类学，并验证源自不同国家的报告为 1v 基因型的毒株的聚类情况。
方法
通过回文核苷酸取代（PNS）基因分型方法评估了最近从中国、土耳其和伊朗中分离的毒株。
结果
基于 5'-UTR 序列的二级结构分析，报告的来自中国的 1v 株被聚类为 sub 基因型 1.7.3（1o）。基因型 1.19（1w）仅限于中国，而基因型 1.21（1v）仅存在于土耳其和伊朗。
结论
PNS 方法的应用阐明了毒株的分类学地位，揭示了遗传上不同聚类的同名现象。此外，这些观察结果表明 A 种在地理上存在分离，并证实了新的非典型遗传变异的发生，这可能对控制和预防产生影响。
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