显微镜下结肠炎患者粪便钙卫蛋白水平：一项系统评价和荟萃分析
Fecal calprotectin level in microscopic colitis: a systematic review and meta-analysis.
作者信息
Songtanin Busara, Kahathuduwa Chanaka, Nugent Kenneth
机构信息
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
出版信息
Proc (Bayl Univ Med Cent). 2023 Jun 14;36(5):641-646. doi: 10.1080/08998280.2023.2223950. eCollection 2023.
BACKGROUND
There are no specific biomarkers for microscopic colitis (MC), and the diagnosis depends on histopathological tissue obtained during colonoscopy. Studies on the role of fecal calprotectin (FCP) in MC are limited. A literature search of PubMed, Embase, and Scopus was conducted from each database's inception through September 2022.
METHODS
A DerSimonian-Liard random-effects meta-analysis was performed to examine the standardized mean difference (SMD) in FCP levels between patients with MC and control patients with chronic diarrhea.
RESULTS
Six studies with 96 active MC patients and 200 controls were included in the meta-analysis. Random effects meta-analysis revealed that FCP was significantly and moderately elevated in patients with MC compared to the control group (SMD = 0.6 [95% CI 0.3, 1.0], = 0.001). Imputing one effect size confirmed the observation that FCP is significantly higher in patients with MC than control subjects with chronic diarrhea (SMD = 0.5 [95% CI 0.2, 0.9], = 0.004). Study heterogeneity between the SMDs was not significant ( = 41%, = 0.1).
CONCLUSION
These results indicate that FCP levels in patients with chronic diarrhea can help identify patients with MC. More studies with serial measurements of FCP would provide a better understanding of its utility in MC.
背景
微观性结肠炎（MC）尚无特异性生物标志物，其诊断依赖于结肠镜检查时获取的组织病理结果。粪便钙卫蛋白（FCP）在MC中的作用研究有限。对PubMed、Embase和Scopus数据库从建库至2022年9月进行了文献检索。
方法
采用DerSimonian-Liard随机效应荟萃分析，以检验MC患者与慢性腹泻对照患者FCP水平的标准化均值差（SMD）。
结果
荟萃分析纳入了6项研究，共96例活动性MC患者和200例对照。随机效应荟萃分析显示，与对照组相比，MC患者的FCP显著且中度升高（SMD = 0.6 [95% CI 0.3, 1.0]，P = 0.001）。推算一个效应量证实了MC患者的FCP显著高于慢性腹泻对照受试者这一观察结果（SMD = 0.5 [95% CI 0.2, 0.9]，P = 0.004）。SMD之间的研究异质性不显著（I² = 41%，P = 0.1）。
结论
这些结果表明，慢性腹泻患者的FCP水平有助于识别MC患者。更多关于FCP系列测量的研究将有助于更好地了解其在MC中的效用。
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