deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells.

are responsible for significant disease burden in humans, ranging from recurrent disease outbreaks (yersiniosis) to pandemics ( plague). Together with rising antibiotic resistance rates, there is a critical need to better understand pathogenesis and host immune mechanisms, as this information will aid in developing improved immunomodulatory therapeutics. Inflammasome responses in human cells are less studied relative to murine models of infection, though recent studies have uncovered key differences in inflammasome responses between mice and humans. Here, we dissect human intestinal epithelial cell and macrophage inflammasome responses to . Our findings provide insight into species- and cell type-specific differences in inflammasome responses to .