Chen Zilin, Wang Xu, Zhang Si, Han Fei
Department of Pediatrics, Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, China.
Experiment Center of Medical Innovation, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Front Psychiatry. 2024 Apr 25;15:1362288. doi: 10.3389/fpsyt.2024.1362288. eCollection 2024.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that encompasses a range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural and functional changes that occur in the nervous system to adapt and respond to changes in the external environment. In simpler terms, it is the brain's ability to learn and adapt to new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory processing, and social cognition, leading to the manifestation of corresponding symptoms. This paper aims to review the current research progress on ASD neuroplasticity, focusing on genetics, environment, neural pathways, neuroinflammation, and immunity. The findings will provide a theoretical foundation and insights for intervention and treatment in pediatric fields related to ASD.
自闭症谱系障碍(ASD)是一种神经发育障碍,其症状包括言语交流困难、社交互动障碍、兴趣有限和重复行为等。神经可塑性是指神经系统发生的结构和功能变化,以适应外部环境的变化并做出反应。简单来说,它是大脑学习和适应新环境的能力。然而,患有ASD的个体表现出异常的神经可塑性,这会影响信息处理、感觉处理和社会认知,从而导致相应症状的表现。本文旨在综述当前关于ASD神经可塑性的研究进展,重点关注遗传学、环境、神经通路、神经炎症和免疫。这些研究结果将为与ASD相关的儿科领域的干预和治疗提供理论基础和见解。