Plant Breeding, Wageningen University and Research, 6708 PB Wageningen, Netherlands.
Department of Plant Biochemistry, Centre of Plant Molecular Biology (ZMBP), University of Tübingen, 72076 Tübingen, Germany.
Science. 2023 Aug 25;381(6660):891-897. doi: 10.1126/science.adg5261. Epub 2023 Aug 24.
Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.
植物细胞表面模式识别受体 (PRRs) 和细胞内免疫受体共同为微生物感染提供免疫。这两种受体家族都以加速的速度共同进化，但 PRRs 的进化和多样化还知之甚少。我们已经分离出马铃薯表面受体 Pep-13 受体单元 (PERU)，它可以感知 Pep-13，这是一种来自植物病原物种的保守免疫原性肽模式。PERU 是一种富含亮氨酸重复受体激酶，是一种真正的 PRR，它结合 Pep-13 并增强对感染的免疫力。PERU 配体结合特异性的多样化可以追溯到安第斯山脉中部的同域野生块茎种群。我们的研究揭示了野生马铃薯种群中细胞表面免疫受体等位基因的进化，这些等位基因识别其他受体不识别的配体变体。
