Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Curr Opin Cell Biol. 2023 Oct;84:102220. doi: 10.1016/j.ceb.2023.102220. Epub 2023 Aug 22.
The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic regulation of lamin filaments through their biogenesis, assembly, disassembly, and degradation. The lamins are unusually long-lived proteins under homeostatic conditions, but their turnover can be induced in select contexts that are highlighted in this review. Finally, we discuss recent investigations into the influence of laminopathy-linked mutations on the assembly, folding, and stability of the nuclear lamins.
核纤层蛋白是聚合的中间丝蛋白，在几乎所有真核细胞中为细胞核提供支架并组织基因组。本综述重点介绍了通过核纤层蛋白的生物发生、组装、解组装和降解来实现其纤维的动态调节。在稳态条件下，核纤层蛋白是异常长寿的蛋白质，但在本综述中强调的特定情况下可以诱导其周转。最后，我们讨论了最近对核纤层蛋白病相关突变对核纤层蛋白组装、折叠和稳定性影响的研究进展。
