Institute of Agricultural Products Processing Technology, Jilin Academy of Agricultural Sciences/National R&D Center for Milk Processing, Changchun 130033, PR China.
Institute of Agricultural Products Processing Technology, Jilin Academy of Agricultural Sciences/National R&D Center for Milk Processing, Changchun 130033, PR China.
Neurosci Lett. 2023 Sep 25;814:137460. doi: 10.1016/j.neulet.2023.137460. Epub 2023 Aug 22.
Growing evidence suggests that probiotics can ameliorate depression by regulating the microbiota-gut-brain axis. However, the mechanism of action of probiotics in depressive disorders remains incompletely understood. This study aimed to investigate the effect of Lacticaseibacillus rhamnosus TF318 in a corticosterone (CORT)-induced rat model of depression. The sucrose preference test (SPT) and Morris water maze (MWM) test showed that oral administration of L. rhamnosus TF318 for 21 d significantly prevented depressive behaviors. Administration of L. rhamnosus TF318 resulted in lower hippocampal levels of adrenocorticotropic hormone and corticotropin-releasing factor and serum levels of CORT and restoration of hippocampal levels of 5-hydroxytryptamine, dopamine, and norepinephrine. A marked increase was observed in the hippocampal concentration of brain-derived neurotrophic factor (BDNF), a change that may have involved the cyclic adenosine monophosphate (cAMP)/cAMP response element-binding (CREB)/BDNF signaling pathway. Treatment with L. rhamnosus TF318 corrected CORT-induced abnormalities in the gut microbiota, significantly increasing the relative abundance of Firmicutes. In conclusion, supplementation with L. rhamnosus TF318 prevented CORT-induced depressive behaviors by upregulating BDNF expression and modulating gut microbiota, suggesting that this strain has the potential as a novel probiotic with antidepressant effects.
越来越多的证据表明，益生菌通过调节微生物群-肠-脑轴可以改善抑郁。然而，益生菌在抑郁症中的作用机制仍不完全清楚。本研究旨在探讨鼠李糖乳杆菌 TF318 在皮质酮（CORT）诱导的大鼠抑郁模型中的作用。蔗糖偏好试验（SPT）和 Morris 水迷宫（MWM）试验表明，口服鼠李糖乳杆菌 TF318 21d 可显著预防抑郁行为。给予鼠李糖乳杆菌 TF318 可导致海马促肾上腺皮质激素和促肾上腺皮质释放因子水平降低，血清皮质酮水平恢复，以及海马 5-羟色胺、多巴胺和去甲肾上腺素水平恢复。观察到海马脑源性神经营养因子（BDNF）浓度明显增加，这种变化可能涉及环磷酸腺苷（cAMP）/cAMP 反应元件结合（CREB）/BDNF 信号通路。鼠李糖乳杆菌 TF318 的治疗纠正了 CORT 引起的肠道微生物群异常，显著增加了厚壁菌门的相对丰度。总之，补充鼠李糖乳杆菌 TF318 通过上调 BDNF 表达和调节肠道微生物群来预防 CORT 诱导的抑郁行为，表明该菌株具有作为新型具有抗抑郁作用的益生菌的潜力。
