Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, P. R. China.
College of Food Science, Northeast Agricultural University, Harbin 150030, P. R. China.
Food Funct. 2022 Apr 20;13(8):4331-4343. doi: 10.1039/d1fo03804d.
Depression remains one of the most prevalent psychiatric disorders, and it has been confirmed that it is related to the dysfunction of the microbiota-gut-brain axis. Manipulation of the gut microenvironment by probiotics might improve mental health and prevent stress-related psychiatric disorders. The present study aimed to determine whether () zz-1 could prevent the occurrence of depression and its potential mechanisms using a mouse model with chronic unpredictable mild stress (CUMS). The results indicated that zz-1 intervention ameliorated CUMS-induced depression-like behaviors of mice with reduced body growth rate, lowered sucrose preference, increased immobility time, as well as decreased curiosity and mobility. Moreover, zz-1 significantly inhibited hormones released due to hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, alleviated CUMS-induced deficits of monoamine neurotransmitters, and increased the expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB). These benefits were partially linked to the regulation of the intestinal microenvironment. zz-1 alleviated intestinal damage and reduced intestinal inflammation of the depressed mice. Meanwhile, zz-1 effectively adjusted the dysbiosis of mouse gut microbiota induced by CUMS, such as changes in the abundance of the NK4A136 group, , and . Taken together, these results demonstrated that zz-1 was effective in preventing depression from chronic stress, adding new evidence to support the mental benefits of probiotics.
抑郁症仍然是最常见的精神障碍之一，并且已经证实它与微生物群-肠道-大脑轴的功能障碍有关。益生菌对肠道微环境的操纵可能改善心理健康并预防与压力相关的精神障碍。本研究旨在使用慢性不可预测轻度应激 (CUMS) 的小鼠模型确定 () zz-1 是否可以预防抑郁症的发生及其潜在机制。结果表明， () zz-1 干预改善了 CUMS 诱导的小鼠抑郁样行为，降低了生长速度，降低了蔗糖偏好，增加了不动时间，并降低了好奇心和活动能力。此外， () zz-1 显著抑制了下丘脑-垂体-肾上腺 (HPA) 轴过度活跃导致的激素释放，减轻了 CUMS 引起的单胺神经递质缺陷，并增加了脑源性神经营养因子 (BDNF) 和酪氨酸激酶受体 B (TrkB) 的表达。这些益处部分与肠道微环境的调节有关。 () zz-1 减轻了抑郁小鼠的肠道损伤和炎症。同时， () zz-1 有效调节了 CUMS 诱导的小鼠肠道微生物群的失调，例如 NK4A136 组丰度的变化， ，和 。综上所述，这些结果表明 () zz-1 对预防慢性应激引起的抑郁症有效，为益生菌的精神益处提供了新的证据。
