School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
The First Affiliated Hospital Of Chengdu Medical College, Chengdu, Sichuan, China.
Neurol Sci. 2024 Aug;45(8):3711-3721. doi: 10.1007/s10072-024-07525-5. Epub 2024 Apr 17.
The intestinal microbiota community is a fundamental component of the human body and plays a significant regulatory role in maintaining overall health and in the management disease states.The intestinal microbiota-gut-brain axis represents a vital connection in the cognitive regulation of the central nervous system by the intestinal microbiota.The impact of intestinal microbiota on cognitive function is hypothesized to manifest through both the nervous system and circulatory system. Imbalances in intestinal microbiota during the perioperative period could potentially contribute to perioperative neurocognitive dysfunction. This article concentrates on a review of existing literature to explore the potential influence of intestinal microbiota on brain and cognitive functions via the nervous and circulatory systems.Additionally, it summarizes recent findings on the impact of perioperative intestinal dysbacteriosis on perioperative neurocognitive dysfunction and suggests novel approaches for prevention and treatment of this condition.
肠道微生物群落是人体的基本组成部分，在维持整体健康和疾病管理方面发挥着重要的调节作用。肠道微生物群-肠道-大脑轴是肠道微生物群通过中枢神经系统进行认知调节的重要连接。肠道微生物群对认知功能的影响可能通过神经系统和循环系统表现出来。围手术期肠道微生物群失衡可能导致围手术期神经认知功能障碍。本文集中回顾了现有文献，探讨了肠道微生物群通过神经系统和循环系统对大脑和认知功能的潜在影响。此外，还总结了围手术期肠道菌群失调对围手术期神经认知功能障碍的影响的最新发现，并提出了预防和治疗这种疾病的新方法。
